EFFECT OF SILVER NANO-PARTICLES ON PASSIVE AVOIDANCE LEARNING IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHODARAHMI P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Armaghane Danesh Year:2015 | Volume:20 | Issue:6 (101) Page(s): 472-482

Download Full-Text

Persian Verion

View:

583

Download:

Cites:

Information Journal Paper

Title

EFFECT OF SILVER NANO-PARTICLES ON PASSIVE AVOIDANCE LEARNING IN RATS

Author(s)

KHODARAHMI P. | Issue Writer Certificate

Keywords

SILVERQ1

NANOPARTICLESQ1

LEARNINGQ2

MEMORYQ2

RATSQ2

Abstract

Background & aim: SILVER NANOPARTICLES (Ag NPs) have been widely used in many technologies to produce medical devices, food technology and textiles. SILVER NANOPARTICLES may be absorbed through the lungs and intestine into circulation and thus may reach such organs as the liver, kidney, spleen, heart and testes and brain. It has been demonstrated that SILVER NANOPARTICLES may have toxic effects on mammalian cells. There are some alarming reports on the adverse effects of SILVER NANOPARTICLES on reproduction of experimental animals. Exposure to SILVER NANOPARTICLES may exert a neurotoxic effect and affect cognitive functions, causing the impairment of short-term and working MEMORY. The purpose of this study was to investigate the possible protective role of Ag NP on the LEARNING and MEMORY of RATS.Methods: The present experimental study was conducted on forty male Wistar RATS weighing 200 to 250 g which were divided into five groups of eight as follows: control group and 4 groups of treatment. Control group RATS received saline and treatment group’s RATS received Ag NP at doses of 50, 250, 500 and 1000 mg/ kg/ day using Intra Peritoneal injection (IP) for 14 days. One day after the last injection, the LEARNING and MEMORY function in the RATS was examined by the passive avoidance task. Measure of MEMORY and LEARNING were assessed using One-Way ANOVA by SPSS using the Tukey s' test.Results: The results showed that Ag NP at dose of 50, 250, 500 mg/kg made no significant change in the STL (step-through latency) and TDC (Time in Dark Compartment), compared to the control group in the passive avoidance task. Despite, Ag NP at dose of 1000 mg/kg significantly reduced the STL (p<0.01) and increased TDC (p<0.001), but no significant change in the number of trials (p>0.05) compared to the control group.Conclusion: These data suggest that ip microinjection of Ag NP could impair LEARNING and MEMORY at high doses.

Cites

No record.

References

No record.

Cite

APA: Copy

KHODARAHMI, P.. (2015). EFFECT OF SILVER NANO-PARTICLES ON PASSIVE AVOIDANCE LEARNING IN RATS. ARMAGHAN DANESH, 20(6 (101)), 472-482. SID. https://sid.ir/paper/77824/en

Vancouver: Copy

KHODARAHMI P.. EFFECT OF SILVER NANO-PARTICLES ON PASSIVE AVOIDANCE LEARNING IN RATS. ARMAGHAN DANESH[Internet]. 2015;20(6 (101)):472-482. Available from: https://sid.ir/paper/77824/en

IEEE: Copy

P. KHODARAHMI, “EFFECT OF SILVER NANO-PARTICLES ON PASSIVE AVOIDANCE LEARNING IN RATS,” ARMAGHAN DANESH, vol. 20, no. 6 (101), pp. 472–482, 2015, [Online]. Available: https://sid.ir/paper/77824/en

Related Journal Papers