Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats

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NETO MORENO DEBORA ANTUNES; Saladini Mirela Santos; Marques Viroel Fabia Judice; Dini Murilo Melo Juste; Pickler Thaisa Borim; Filho Jorge Amaral; dos Santos Carolina Alves; Hanai Yoshida Valquiria Miwa; Grotto Denise; Gerenutti Marli; Hyslop Stephen; OSHIMA FRANCO YOKO

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Journal: Advanced Pharmaceutical Bulletin Year:2021 | Volume:11 | Issue:1 Page(s): 130-136

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Title

Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats

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Abstract

Purpose: In this work, the potential usefulness of silver nanoparticles (AgNPs) for treating burn wounds was examined. Methods: Second-degree burns were induced in male Wistar rats by touching the skin with a heated (70° C) metallic device for 10 s, after which the animals were randomly allocated to one of two groups: control (n=8, treated with sterile saline) and experimental (n=8, treated with AgNPs, 0. 081 mg/mL; 50 μ L applied to the burn surface). Seven, 14, 21 and 28 days after lesion induction two rats from each group were killed and blood samples were collected for a complete blood count and to assess oxidative stress. The livers were examined macroscopically and skin samples were collected for histological analysis. Results: Macroscopically, wound healing and skin remodeling in the experimental group were similar to the saline-treated rats. Likewise, there were no significant differences in the histological parameters between the two groups. However, treatment with AgNPs caused a persistent reduction in white blood cell (WBC) counts throughout the experiment, whereas platelet counts increased on days 7 and 28 but decreased on days 14 and 21; there was also an increase in the blood concentration of reduced glutathione on day 7 followed by a decrease on days 21 and 28. There were no significant changes in blood glutathione peroxidase (GSHPx) and catalase (CAT) activities or in the serum concentration of thiobarbituric acid reactive substances. Conclusion: The findings of this study raise questions about the potential transitory effects of AgNPs based on the changes in WBC and platelet counts, blood glutathione concentrations and macroscopic hepatic alterations.

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APA: Copy

NETO MORENO, DEBORA ANTUNES, Saladini, Mirela Santos, Marques Viroel, Fabia Judice, Dini, Murilo Melo Juste, Pickler, Thaisa Borim, Filho, Jorge Amaral, dos Santos, Carolina Alves, Hanai Yoshida, Valquiria Miwa, Grotto, Denise, Gerenutti, Marli, Hyslop, Stephen, & OSHIMA FRANCO, YOKO. (2021). Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats. ADVANCED PHARMACEUTICAL BULLETIN, 11(1), 130-136. SID. https://sid.ir/paper/778574/en

Vancouver: Copy

NETO MORENO DEBORA ANTUNES, Saladini Mirela Santos, Marques Viroel Fabia Judice, Dini Murilo Melo Juste, Pickler Thaisa Borim, Filho Jorge Amaral, dos Santos Carolina Alves, Hanai Yoshida Valquiria Miwa, Grotto Denise, Gerenutti Marli, Hyslop Stephen, OSHIMA FRANCO YOKO. Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2021;11(1):130-136. Available from: https://sid.ir/paper/778574/en

IEEE: Copy

DEBORA ANTUNES NETO MORENO, Mirela Santos Saladini, Fabia Judice Marques Viroel, Murilo Melo Juste Dini, Thaisa Borim Pickler, Jorge Amaral Filho, Carolina Alves dos Santos, Valquiria Miwa Hanai Yoshida, Denise Grotto, Marli Gerenutti, Stephen Hyslop, and YOKO OSHIMA FRANCO, “Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 11, no. 1, pp. 130–136, 2021, [Online]. Available: https://sid.ir/paper/778574/en

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