Docetaxel Toxicity Optimization in Esophageal Squamous Cell Carcinoma Cell Line YM-1: A Study of Cell Cycle and Doubling Time Effect

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Haghi Boshra; SAGHAEIAN JAZI MARIE; ZAREI MAHDI; Khosravi Ayyob; Tajaldini Mahboubeh; ASADI JAHANBAKHSH

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Journal: MEDICAL LABORATORY JOURNAL Year:2021 | Volume:15 | Issue:2 Page(s): 18-22

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Title

Docetaxel Toxicity Optimization in Esophageal Squamous Cell Carcinoma Cell Line YM-1: A Study of Cell Cycle and Doubling Time Effect

Author(s)

Keywords

Docetaxel

Cell cycle

Esophageal Neoplasms

Abstract

Background and objectives: Docetaxel is a chemotherapeutic agent commonly used for treatment of many cancers, including esophageal squamous cell carcinoma. Docetaxel induces G2/M phase Cell cycle arrest and ultimately cell death. In this study, we aimed to assess the effects of Docetaxel on YM1 cells considering exposure time and dose. Methods: After calculating the doubling time of YM1 cells, the anti-proliferative effect of different concentrations of Docetaxel (0. 1-10 nM) after 24, 48 and 72 hours was assessed by the standard colorimetric assay. In addition, the effect of Docetaxel on Cell cycle was evaluated by flow cytometry. Results: The results showed that Docetaxel toxicity was not significant until 24 hours at the tested concentrations (P>0. 05). In addition, the effect of Docetaxel on the cells was time-dependent at all tested concentrations. Overall, the duration of exposure to Docetaxel had more significant role in Docetaxel toxicity in YM1 cells compared to concentration. Conclusion: Our findings suggest that the cytotoxicity of Docetaxel on YM1 cells is time-dependent.

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APA: Copy

Haghi, Boshra, SAGHAEIAN JAZI, MARIE, ZAREI, MAHDI, Khosravi, Ayyob, Tajaldini, Mahboubeh, & ASADI, JAHANBAKHSH. (2021). Docetaxel Toxicity Optimization in Esophageal Squamous Cell Carcinoma Cell Line YM-1: A Study of Cell Cycle and Doubling Time Effect. MEDICAL LABORATORY JOURNAL, 15(2), 18-22. SID. https://sid.ir/paper/778888/en

Vancouver: Copy

Haghi Boshra, SAGHAEIAN JAZI MARIE, ZAREI MAHDI, Khosravi Ayyob, Tajaldini Mahboubeh, ASADI JAHANBAKHSH. Docetaxel Toxicity Optimization in Esophageal Squamous Cell Carcinoma Cell Line YM-1: A Study of Cell Cycle and Doubling Time Effect. MEDICAL LABORATORY JOURNAL[Internet]. 2021;15(2):18-22. Available from: https://sid.ir/paper/778888/en

IEEE: Copy

Boshra Haghi, MARIE SAGHAEIAN JAZI, MAHDI ZAREI, Ayyob Khosravi, Mahboubeh Tajaldini, and JAHANBAKHSH ASADI, “Docetaxel Toxicity Optimization in Esophageal Squamous Cell Carcinoma Cell Line YM-1: A Study of Cell Cycle and Doubling Time Effect,” MEDICAL LABORATORY JOURNAL, vol. 15, no. 2, pp. 18–22, 2021, [Online]. Available: https://sid.ir/paper/778888/en

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