LACTATE TRANSPORTERS EXPRESSION IN TUMOR OF BALB/C MICE BEARING BREAST CANCER AFTER ENDURANCE TRAINING

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AVESEH M.; NIKOOIE R.; AMINAIE M.

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Journal: Armaghane Danesh Year:2014 | Volume:19 | Issue:7 (90) Page(s): 602-613

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Title

LACTATE TRANSPORTERS EXPRESSION IN TUMOR OF BALB/C MICE BEARING BREAST CANCER AFTER ENDURANCE TRAINING

Author(s)

AVESEH M. | NIKOOIE R. | AMINAIE M. | Issue Writer Certificate

Keywords

ENDURANCE TRAININGQ1

BREAST CANCERQ1

LACTATEQ2

MONOCARBOXYLATE TRANSPORTERSQ2

Abstract

Background & aim: Changes in the metabolism of cancer cells plays a major role in the survival and their expansion. The aim of this study was to determine expression of LACTATE transmitters in Balb/c mice with BREAST CANCER after ENDURANCE TRAINING.Methods: In this experimental study twenty-five Balb C mice were randomly divided into two groups of BREAST CANCER control (N=13) and BREAST CANCER training (N=12). BREAST CANCER was induced in mammary fat pad by injection of cancer cells (MC4L2) in mice and ENDURANCE TRAINING protocol was applied for 7 weeks in the experimental group. Tumor volume and MCT1, MCT4, and CD147 expression were measured by micro digital caliper and western blotting technique respectively. Data were analyzed statistically using Student t and Pearson.Results: Significant decreases was found in weight and CD147 expression of tumor after 7 weeks of ENDURANCE TRAINING in the exercise group compared to the control group. No significant differences were seen in MCT4 expression and tumor volume between the groups (05 / 0p>0.05). Significant correlation was found between tumor MCT1 and CD147 expression (P<0.05), while the relationship between MCT4 and CD147 expression in tumors was not statistically significant.Conclusion: ENDURANCE TRAINING can reduce LACTATE metabolism in cancer cells through suppression of LACTATE transporters expression and provides a useful tool in BREAST CANCER treatment or prevention.

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APA: Copy

AVESEH, M., NIKOOIE, R., & AMINAIE, M.. (2014). LACTATE TRANSPORTERS EXPRESSION IN TUMOR OF BALB/C MICE BEARING BREAST CANCER AFTER ENDURANCE TRAINING. ARMAGHAN DANESH, 19(7 (90)), 602-613. SID. https://sid.ir/paper/77944/en

Vancouver: Copy

AVESEH M., NIKOOIE R., AMINAIE M.. LACTATE TRANSPORTERS EXPRESSION IN TUMOR OF BALB/C MICE BEARING BREAST CANCER AFTER ENDURANCE TRAINING. ARMAGHAN DANESH[Internet]. 2014;19(7 (90)):602-613. Available from: https://sid.ir/paper/77944/en

IEEE: Copy

M. AVESEH, R. NIKOOIE, and M. AMINAIE, “LACTATE TRANSPORTERS EXPRESSION IN TUMOR OF BALB/C MICE BEARING BREAST CANCER AFTER ENDURANCE TRAINING,” ARMAGHAN DANESH, vol. 19, no. 7 (90), pp. 602–613, 2014, [Online]. Available: https://sid.ir/paper/77944/en

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