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Information Journal Paper

Title

The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma

Pages

  31-34

Abstract

 Background: Acromegaly defines as chronic elevations of insulin-like growth factor-1 (IGF-1) and growth hormone (GH), which results in enlargement of organs and soft tissues. Cardiovascular complications of Acromegaly such as Cardiomegaly, hypertension contributing to a high risk of cardiovascular events. This study aimed to identify the determinants of the prevalence of Cardiomegaly as cardiovascular comorbidity of Acromegaly and the potential effect of the curative intervention. Methods: A total of 160 patients with Acromegaly due to pituitary adenoma participated in this study. Acromegaly diagnosed was based on clinical manifestations, age-adjusted plasma IGF-I, and elevated plasma GH levels, not suppressible during an oral glucose tolerance test (75 g). Electrocardiogram and chest X-ray obtained in all patients. Treatment approaches included Transsphenoidal surgery and hormonal evaluation performed before and six months after surgery. Results: The GH serum level was elevated in all patients before surgery, with a mean of 33. 7 ng/mL that reached 5. 7 ng/mL after surgery. Mean IGF-1 was 794. 1 ng/mL that reached 395. 6 ng/mL postoperatively. The prevalence of Cardiomegaly was 15% that improved in 5% of patients after trans sphenoidal surgery. Conclusion: Appropriate surgical intervention in Acromegaly that complicated by Cardiomegaly may result in significant improvement of the cardiac structure.

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    APA: Copy

    EBRAHIMZADEH, KAVEH, Mojtabavi, Kurosh, Mohammadi, Sasan, Farahani, Mehrdad, Gholizadeh Ghozloujeh, Zohreh, ASAADI, SINA, SHARIFI, GUIVE, Joshaghanian, Mohammad Amin, & REZAEI, OMIDVAR. (2020). The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL, 7(1), 31-34. SID. https://sid.ir/paper/779729/en

    Vancouver: Copy

    EBRAHIMZADEH KAVEH, Mojtabavi Kurosh, Mohammadi Sasan, Farahani Mehrdad, Gholizadeh Ghozloujeh Zohreh, ASAADI SINA, SHARIFI GUIVE, Joshaghanian Mohammad Amin, REZAEI OMIDVAR. The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL[Internet]. 2020;7(1):31-34. Available from: https://sid.ir/paper/779729/en

    IEEE: Copy

    KAVEH EBRAHIMZADEH, Kurosh Mojtabavi, Sasan Mohammadi, Mehrdad Farahani, Zohreh Gholizadeh Ghozloujeh, SINA ASAADI, GUIVE SHARIFI, Mohammad Amin Joshaghanian, and OMIDVAR REZAEI, “The Therapeutic Effect of Endoscopic Tumor Resection on Acromegalic Cardiomegaly in Patients With Pituitary Adenoma,” INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL, vol. 7, no. 1, pp. 31–34, 2020, [Online]. Available: https://sid.ir/paper/779729/en

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