Quantitation of Colonic Cells as Severity Markers in Patients with Irritable Bowel Syndrome

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MIRI MOHAMMAD BAGHER; SADEGHI AMIR; MORADI AFSHIN; ROSTAMI NEJAD MOHAMMAD; ASADZADEH AGHDAEI HAMID; ehsani ardekani mohammad javad; SAFARI MOHAMMAD TAGHI; ZALI MOHAMMAD REZA

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Journal: Galen Medical Journal Year:2018 | Volume:7 | Issue:1 Page(s): 0-0

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Title

Quantitation of Colonic Cells as Severity Markers in Patients with Irritable Bowel Syndrome

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Keywords

Irritable Bowel Syndrome

Biopsy

Intra-epithelial Lymphocytes

Abstract

Background: Irritable Bowel Syndrome (IBS) is the most common gastrointestinal syndrome. Routine histopathology and immunohistochemistry (IHC) evaluations have shown an increase in the number of different inflammatory cells in the colon of IBS patients. In this study, we have compared the number of intraepithelial lymphocytes (IELs), eosinophils, mast cells and CD3+ T cells, in IBS patients and normal subjects. Materials and Methods: In 2016, seventynine patients with IBS and seventy-nine healthy subjects who underwent colonoscopy for other non-specific causes and with no pathologic findings, were enrolled in this cross-sectional study. Biopsy specimens obtained from the colon were stained, using IHC methods to determine the number of IELs, eosinophils, mast cells and CD3+ T cells. Quantitative and qualitative variables were compared between the two groups, using a Chi-square test and Student’ s t-test. Results: Seventy-nine patients with IBS, 79. 7% females with a mean age of 42. 5± 14. 6 years, were recruited, as the case group, and seventy-nine individuals, 51. 9% females with a mean age of 39. 7± 18. 9 years, were enrolled as controls. The average number of IELs per high power fields (hpf) was found to be higher in the IBS group, and this difference was statistically significant (32. 8± 11. 8 vs. 28. 6± 12. 9; P=0. 034). Also, the mean count/hpf of CD3+ T lymphocytes (23. 1± 7. 9 vs. 20. 2± 8. 1; P=0. 024) and mast cells (7. 6± 3. 1 vs. 6. 6± 3. 0; P=0. 041) were significantly higher in the IBS group, compared to the control group. The number of eosinophils was higher in the IBS group, but the differences were not statistically significant (P=0. 066). Conclusion: According to the results, we suggest that analysis of immune cells and IELs in intestinal biopsies might be an appropriate method for diagnosis of IBS.

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APA: Copy

MIRI, MOHAMMAD BAGHER, SADEGHI, AMIR, MORADI, AFSHIN, ROSTAMI NEJAD, MOHAMMAD, ASADZADEH AGHDAEI, HAMID, ehsani ardekani, mohammad javad, SAFARI, MOHAMMAD TAGHI, & ZALI, MOHAMMAD REZA. (2018). Quantitation of Colonic Cells as Severity Markers in Patients with Irritable Bowel Syndrome. GALEN MEDICAL JOURNAL, 7(1), 0-0. SID. https://sid.ir/paper/780282/en

Vancouver: Copy

MIRI MOHAMMAD BAGHER, SADEGHI AMIR, MORADI AFSHIN, ROSTAMI NEJAD MOHAMMAD, ASADZADEH AGHDAEI HAMID, ehsani ardekani mohammad javad, SAFARI MOHAMMAD TAGHI, ZALI MOHAMMAD REZA. Quantitation of Colonic Cells as Severity Markers in Patients with Irritable Bowel Syndrome. GALEN MEDICAL JOURNAL[Internet]. 2018;7(1):0-0. Available from: https://sid.ir/paper/780282/en

IEEE: Copy

MOHAMMAD BAGHER MIRI, AMIR SADEGHI, AFSHIN MORADI, MOHAMMAD ROSTAMI NEJAD, HAMID ASADZADEH AGHDAEI, mohammad javad ehsani ardekani, MOHAMMAD TAGHI SAFARI, and MOHAMMAD REZA ZALI, “Quantitation of Colonic Cells as Severity Markers in Patients with Irritable Bowel Syndrome,” GALEN MEDICAL JOURNAL, vol. 7, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/780282/en

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