THE EFFECTS OF SHISHEH ON THE HORMONAL AXIS HYPOTHALAMUS-PITUITARY-THYROID FUNCTION IN ADULT MALE WISTAR RATS

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AHMADI R.; AMINI N.; GHASEMI A.; SEIF A.

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Journal: Armaghane Danesh Year:2014 | Volume:19 | Issue:8 (91) Page(s): 685-693

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Title

THE EFFECTS OF SHISHEH ON THE HORMONAL AXIS HYPOTHALAMUS-PITUITARY-THYROID FUNCTION IN ADULT MALE WISTAR RATS

Author(s)

AHMADI R. | AMINI N. | GHASEMI A. | SEIF A. | Issue Writer Certificate

Keywords

SHISHEHQ2

T3Q2

T4Q3

TSHQ3

RATQ2

Abstract

Background & aim: Studies show that amphetamines can influence the hypothalamic-pituitarythyroid axis. The aim of this study was to investigate the effects of SHISHEH (met-amphetamine) on serum levels of T3, T4 and TSH in male RATs.Methods: In this laboratory experimental study 25 male Wistar RATs were randomly divided to control, saline receiving, 2mg/kg, 4mg/kg, and 6mg/kg of SHISHEH receiving groups of 5 RATs in each. The injection was carried out intraperitoneally once a week for 6 weeks. After serum collection, T3, T4 and TSH levels were measured using ELFA method and the data were statically analyzed using ANOVA.Results: Serum level of T3 and T4 was not significantly changed in RATs receiving 2mg/kg of SHISHEH compared with control animals. Serum level of T3 and T4 was signifintly increased in animals receiving4mg/kg and 6mg/kg dose of SHISHEH compared with the control RATs (P<0.05 ,\P<0.001, respectively). Serum TSH level was significantly increased in RATs receiving 2mg/kg, 4mg/kg, and 6mg/kg of SHISHEH compared with control animals (P<0.001).Conclusion: Our results indicate that SHISHEH injection can enhance thyroid gland activity via acting on pituitary-thyroid axis, resulting in increased serum T3, T4 and TSH.

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APA: Copy

AHMADI, R., AMINI, N., GHASEMI, A., & SEIF, A.. (2014). THE EFFECTS OF SHISHEH ON THE HORMONAL AXIS HYPOTHALAMUS-PITUITARY-THYROID FUNCTION IN ADULT MALE WISTAR RATS. ARMAGHAN DANESH, 19(8 (91)), 685-693. SID. https://sid.ir/paper/78039/en

Vancouver: Copy

AHMADI R., AMINI N., GHASEMI A., SEIF A.. THE EFFECTS OF SHISHEH ON THE HORMONAL AXIS HYPOTHALAMUS-PITUITARY-THYROID FUNCTION IN ADULT MALE WISTAR RATS. ARMAGHAN DANESH[Internet]. 2014;19(8 (91)):685-693. Available from: https://sid.ir/paper/78039/en

IEEE: Copy

R. AHMADI, N. AMINI, A. GHASEMI, and A. SEIF, “THE EFFECTS OF SHISHEH ON THE HORMONAL AXIS HYPOTHALAMUS-PITUITARY-THYROID FUNCTION IN ADULT MALE WISTAR RATS,” ARMAGHAN DANESH, vol. 19, no. 8 (91), pp. 685–693, 2014, [Online]. Available: https://sid.ir/paper/78039/en

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