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Information Journal Paper

Title

Effects of Selenium Nanoparticles on Biochemical Parameters and Histopathological Changes in Lead-intoxicated Rats

Pages

  35-40

Abstract

 Background: Lead pollution-a major environmental problems in industrial countries-is associated with health problems. The present study aimed to investigate the protective effects of Selenium nanoparticles in a lead-induced testicular Toxicity model. Methods: In total, 30 Wistar rats were divided into three groups and treated (except the normal control) with Lead acetate in drinking water (1, 000 mg/l) for five weeks. The negative and positive control rats received saline intraperitoneally, and the third group received intraperitoneal injections of Selenium nanoparticles (0. 5 mg/kg). Results: The lead-treated group showed a significant increase in blood urea nitrogen, serum creatinine, serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), and malondialdehyde levels (P < 0. 01). The lead-intoxicated rats treated with Selenium nanoparticles showed a significant decrease in serum AST and ALT compared to the untreated negative controls (P < 0. 5). The histopathological examination of Liver and Kidney tissues indicated lead-induced injuries (e. g., necrotic cells in Liver and Kidneys). The selenium-treated group showed reduced histopathological signs of lead-induced injuries. Lipid peroxidation levels were also lower in the selenium-treated rats compared to the negative controls (P < 0. 05). Conclusion: This experimental study confirmed the protective effects of Selenium nanoparticles in the rats exposed to chronic lead-induced Toxicity. However, further experiments are required to evaluate the possible side-effects and complications.

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    Cite

    APA: Copy

    HAJINEZHAD, MOHAMMAD REZA. (2021). Effects of Selenium Nanoparticles on Biochemical Parameters and Histopathological Changes in Lead-intoxicated Rats. JOURNAL OF HUMAN, ENVIRONMENT AND HEALTH PROMOTION, 7(1), 35-40. SID. https://sid.ir/paper/782233/en

    Vancouver: Copy

    HAJINEZHAD MOHAMMAD REZA. Effects of Selenium Nanoparticles on Biochemical Parameters and Histopathological Changes in Lead-intoxicated Rats. JOURNAL OF HUMAN, ENVIRONMENT AND HEALTH PROMOTION[Internet]. 2021;7(1):35-40. Available from: https://sid.ir/paper/782233/en

    IEEE: Copy

    MOHAMMAD REZA HAJINEZHAD, “Effects of Selenium Nanoparticles on Biochemical Parameters and Histopathological Changes in Lead-intoxicated Rats,” JOURNAL OF HUMAN, ENVIRONMENT AND HEALTH PROMOTION, vol. 7, no. 1, pp. 35–40, 2021, [Online]. Available: https://sid.ir/paper/782233/en

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