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Information Journal Paper

Title

Roles of miRNAs in Colorectal Cancer: Therapeutic Implications and Clinical Opportunities (Review Article)

Pages

  233-247

Abstract

 Colorectal cancer (CRC) is one of the most disseminated diseases across the globe engaging the digestive system. Various therapeutic methods from traditional to the state-of-the-art ones have been applied in CRC patients, however, the attempts have been unfortunate to lead to a definite cure. miRNAs are a smart group of non-coding RNAs having the capabilities of regulating and controlling coding genes. By utilizing this stock-in-trade biomolecules, not only disease’ s symptoms can be eliminated, there may also be a good chance for the complete cure of the disease in the near future. Herein, we provide a comprehensive review delineating the therapeutic relationship between miRNAs and CRC. To this, various clinical aspects of miRNAs which act as a tumor suppressor and/or an oncogene, their underlying cellular processes and clinical outcomes, and, in particular, their effects and expression level changes in patients treated with chemo-and Radiotherapy are discussed. Finally, based on the results deducted from scientific research studies, therapeutic opportunities based on targeting/utilizing miRNAs in the preclinical as well as clinical settings are highlighted.

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    APA: Copy

    Mehrgou, Amir, Ebadollahi, Shima, Seidi, Khaled, Ayoubi Joshaghani, Mohammad Hosein, Ahmadieh Yazdi, Amirhossein, ZARE, PEYMAN, JAYMAND, MEHDI, & Jahanban Esfahlan, Rana. (2021). Roles of miRNAs in Colorectal Cancer: Therapeutic Implications and Clinical Opportunities (Review Article). ADVANCED PHARMACEUTICAL BULLETIN, 11(2), 233-247. SID. https://sid.ir/paper/782899/en

    Vancouver: Copy

    Mehrgou Amir, Ebadollahi Shima, Seidi Khaled, Ayoubi Joshaghani Mohammad Hosein, Ahmadieh Yazdi Amirhossein, ZARE PEYMAN, JAYMAND MEHDI, Jahanban Esfahlan Rana. Roles of miRNAs in Colorectal Cancer: Therapeutic Implications and Clinical Opportunities (Review Article). ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2021;11(2):233-247. Available from: https://sid.ir/paper/782899/en

    IEEE: Copy

    Amir Mehrgou, Shima Ebadollahi, Khaled Seidi, Mohammad Hosein Ayoubi Joshaghani, Amirhossein Ahmadieh Yazdi, PEYMAN ZARE, MEHDI JAYMAND, and Rana Jahanban Esfahlan, “Roles of miRNAs in Colorectal Cancer: Therapeutic Implications and Clinical Opportunities (Review Article),” ADVANCED PHARMACEUTICAL BULLETIN, vol. 11, no. 2, pp. 233–247, 2021, [Online]. Available: https://sid.ir/paper/782899/en

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