RELATIONSHIP BETWEEN HA-1 DISPARITY AND ACUTE GVHD AFTER HEMATOPOIETIC STEM CELL TRANSPLANATION

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SHAIGAN MOZHGAN; MOHAMMADI S.; SAMIEI SH.; ALI MOGHADAM K.; BABAEI GHOLAM REZA; GHASHGHAEI A.; ROSTAMI SH.; KHATAMI F.; AZAR KEYVAN A.; ZOU ALFAGHARI ANARAKI S.; ATAEI Z.; GHAVAMZADEH ARDESHIR

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Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2009 | Volume:6 | Issue:1 (22) Page(s): 31-40

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Title

RELATIONSHIP BETWEEN HA-1 DISPARITY AND ACUTE GVHD AFTER HEMATOPOIETIC STEM CELL TRANSPLANATION

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Keywords

POLYMERASE CHAIN REACTIONQ3

GRAFT- VERSUS – HOST DISEASEQ3

MINOR HISTOCOMPATIBILITY ANTIGENSQ3

HEMATOPOIETIC STEM CELL TRANSPLANTATIONQ3

Abstract

Background and Objectives: It is suggested that HA-1 mismatching among hematopoietic stem cell recipients-donors be associated with acute graft-versus-host disease (aGVHD). So the aim of this study was to evaluate HA-1 frequency and examine the correlation between HA-1 disparity and GVHD patients who received transplantation from HLA-A2 identical siblings.Materials and Methods: Extracted DNA samples were collected from 55 HLA-A2-positive donor-recipient pairs. All the patients received peripheral blood stem cell transplant (PSCT) from HLA-identical siblings. HA-1 was detected by SSP-PCR method. The HA-1 typing was performed using SSP method. Data were analyzed using Chi-square, Man withney and Z test with SPSS 11.5.Results: Thirty patients showed to be GVHD I-IV and 25 pairs were without any GVHD signs. The frequency rates of HA-1R and HA-1H alleles in patients were 0.55 and 0.45, respectively; it showed no significant difference with the frequency rates (0.53 and 0.47) of this allels in donors (p>0.05). HA-1 disparity was detected in 8 out of the 55 donor/recipient pairs (14.5%). aGVHD (grades I-IV) was occurred in 6 of patients. Two patients with HA-1 disparity did not show any GVHD signs. X2 test showed there was not any relationship between the incidence of acute graft-versus-host-disease (aGVHD) and HA-1 incompatibility in the patient. Conclusions: In spite of higher frequency of HA-1 disparity in GVHD+ group, our data did not reflect any significant association between HA-1 disparity and risk of acute GVHD.

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APA: Copy

SHAIGAN, MOZHGAN, MOHAMMADI, S., SAMIEI, SH., ALI MOGHADAM, K., BABAEI, GHOLAM REZA, GHASHGHAEI, A., ROSTAMI, SH., KHATAMI, F., AZAR KEYVAN, A., ZOU ALFAGHARI ANARAKI, S., ATAEI, Z., & GHAVAMZADEH, ARDESHIR. (2009). RELATIONSHIP BETWEEN HA-1 DISPARITY AND ACUTE GVHD AFTER HEMATOPOIETIC STEM CELL TRANSPLANATION. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 6(1 (22)), 31-40. SID. https://sid.ir/paper/78337/en

Vancouver: Copy

SHAIGAN MOZHGAN, MOHAMMADI S., SAMIEI SH., ALI MOGHADAM K., BABAEI GHOLAM REZA, GHASHGHAEI A., ROSTAMI SH., KHATAMI F., AZAR KEYVAN A., ZOU ALFAGHARI ANARAKI S., ATAEI Z., GHAVAMZADEH ARDESHIR. RELATIONSHIP BETWEEN HA-1 DISPARITY AND ACUTE GVHD AFTER HEMATOPOIETIC STEM CELL TRANSPLANATION. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2009;6(1 (22)):31-40. Available from: https://sid.ir/paper/78337/en

IEEE: Copy

MOZHGAN SHAIGAN, S. MOHAMMADI, SH. SAMIEI, K. ALI MOGHADAM, GHOLAM REZA BABAEI, A. GHASHGHAEI, SH. ROSTAMI, F. KHATAMI, A. AZAR KEYVAN, S. ZOU ALFAGHARI ANARAKI, Z. ATAEI, and ARDESHIR GHAVAMZADEH, “RELATIONSHIP BETWEEN HA-1 DISPARITY AND ACUTE GVHD AFTER HEMATOPOIETIC STEM CELL TRANSPLANATION,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 6, no. 1 (22), pp. 31–40, 2009, [Online]. Available: https://sid.ir/paper/78337/en

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