PREVALENCE OF THYROID DYSFUNCTION AND RELEVANT RISK FACTORS AMONG THALASSMIA PATIENTS HAVING REFERRED TO IRANIAN BLOOD TRANFUSION ORGANIZATION CLINICAL LABORATORY OF TEHRAN

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JALALI FARAAHANI F.; ZOU ALFAGHARI ANARAKI S.; TALEBIAN A.; AZAR KEYVAN A.; MAGHSOUD LOU M.; SARMADI MEHRNOUSH; FATEMI SHIVA; SHAHRABI AKRAM; TAHERKHANI Z.

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Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2009 | Volume:6 | Issue:1 (22) Page(s): 59-64

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Title

PREVALENCE OF THYROID DYSFUNCTION AND RELEVANT RISK FACTORS AMONG THALASSMIA PATIENTS HAVING REFERRED TO IRANIAN BLOOD TRANFUSION ORGANIZATION CLINICAL LABORATORY OF TEHRAN

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Keywords

THALASSEMIAQ3

THYROID GLANDQ3

HYPOTHYROIDISMQ3

Abstract

Background and Objectives : THALASSEMIA is the most common hereditary anemia in Iran. Despite improved hematologic care, multi endocrine dysfunction is a common complication in these patients. The main objective of this study was to estimate the prevalence of thyroid dysfunction in patients including both THALASSEMIA major and THALASSEMIA intermedia.Materials and Methods: In this descriptive cross sectional study, a questionnaire was designed for 195 patients who were reffered to Iranian Blood Transfusion Organization Clinical Laboratory of Tehran from THALASSEMIA Clinic in Winter 2007. The following items were brought up in the questionnaire: sex, age, height, weight, splenectomy time, amount of transfused blood, blood transfusion interval, desferoxamine dosage, type of THALASSEMIA (major or intermedia), serum thyroid hormones, and ferritin levels. Then, the correlation of thyroid functional status with age, serum ferritin level, type of THALASSEMIA, splenectomy and desferoxamine dosage was evaluated in both F THALASSEMIA major and THALASSEMIA intermedia groups.Results: We had 178(91.3%) F THALASSEMIA major (50.6% male, 49.4% female with the mean age of 17.2 ± 8 years) and 17(8.7%) THALASSEMIA intermedia (23.5% male, 76.5% female with the mean age of 23.2 ± 8.8 years). One hundred sixty two (83.1%) patients were euthyroid, 27 (13.8%) had subclinical HYPOTHYROIDISM (CI 95%= 9-18.6), and 6(3.1%) were primary hypothyroid (CI 95% = 0.7-5.5). Mean ferritin levels for euthyroid group were 1923 ± 1470 ng/ml, for subclinical HYPOTHYROIDISM group 1723 ± 1346 ng/ml, and for primary HYPOTHYROIDISM 1569 ± 734 ng/ml, respectively. No significant correlation was found between abnormal thyroid function (subclinical and primary HYPOTHYROIDISM) and serum ferritin levels (p=0.55), age (p=0.11) , type of THALASSEMIA (p=0.68), splenectomy (p=0.62) and desferoxamine dosage (p=0.33).Conclusions :Based on our results, THALASSEMIA patients present a sort of thyroid dysfunction such as HYPOTHYROIDISM. So, more effective treatment with desferoxamine and regular follow up of patients for evaluation of thyroid function satus are recommended.

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APA: Copy

JALALI FARAAHANI, F., ZOU ALFAGHARI ANARAKI, S., TALEBIAN, A., AZAR KEYVAN, A., MAGHSOUD LOU, M., SARMADI, MEHRNOUSH, FATEMI, SHIVA, SHAHRABI, AKRAM, & TAHERKHANI, Z.. (2009). PREVALENCE OF THYROID DYSFUNCTION AND RELEVANT RISK FACTORS AMONG THALASSMIA PATIENTS HAVING REFERRED TO IRANIAN BLOOD TRANFUSION ORGANIZATION CLINICAL LABORATORY OF TEHRAN. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 6(1 (22)), 59-64. SID. https://sid.ir/paper/78341/en

Vancouver: Copy

JALALI FARAAHANI F., ZOU ALFAGHARI ANARAKI S., TALEBIAN A., AZAR KEYVAN A., MAGHSOUD LOU M., SARMADI MEHRNOUSH, FATEMI SHIVA, SHAHRABI AKRAM, TAHERKHANI Z.. PREVALENCE OF THYROID DYSFUNCTION AND RELEVANT RISK FACTORS AMONG THALASSMIA PATIENTS HAVING REFERRED TO IRANIAN BLOOD TRANFUSION ORGANIZATION CLINICAL LABORATORY OF TEHRAN. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2009;6(1 (22)):59-64. Available from: https://sid.ir/paper/78341/en

IEEE: Copy

F. JALALI FARAAHANI, S. ZOU ALFAGHARI ANARAKI, A. TALEBIAN, A. AZAR KEYVAN, M. MAGHSOUD LOU, MEHRNOUSH SARMADI, SHIVA FATEMI, AKRAM SHAHRABI, and Z. TAHERKHANI, “PREVALENCE OF THYROID DYSFUNCTION AND RELEVANT RISK FACTORS AMONG THALASSMIA PATIENTS HAVING REFERRED TO IRANIAN BLOOD TRANFUSION ORGANIZATION CLINICAL LABORATORY OF TEHRAN,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 6, no. 1 (22), pp. 59–64, 2009, [Online]. Available: https://sid.ir/paper/78341/en

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