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Title

Corticosteroid Therapy in Management of Myocarditis Associated with COVID-19; a Systematic Review of Current Evidence

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Abstract

 Introduction: myocarditis in patients infected with severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) seems to be associated with a higher mortality rate. This study aims to summarize the latest evidence on whether the use of corticosteroids in patients with myocarditis associated with COVID-19 is necessary. Methods: We performed an extensive search using a combination of search terms in PubMed, Europe PMC, ProQuest, EBSCOhost, and Google Scholar up to January 2021. Full-text articles that met the predefined inclusion criteria were included in the present study. Results: The full-texts of 18 articles have been reviewed. Thirteen out of the eighteen (72%) patients who got corticosteroid administration experiencedmajor clinical improvements during follow-up while the other five (28%)were experiencing uneventful events. The mean age of the reported patients was 47. 8± 13. 2 years. There was no gender predominance. Most of the reported cases were from USA (39%) followed by Spain, China, and UK (11% each), while Brazil, Colombia, France, Belgium, and Italy contributed one case each. Various corticosteroids were used but the most commonly applied were methylprednisolone (89%), hydrocortisone (5. 5%), and prednisolone (5. 5%). The most common route of administration among the studies was intravenous administration and the duration of treatment varied between one and fourteen days. Conclusion: A review of the currently available literature shows that with the use of corticosteroid agents in treating myocarditis associated with COVID-19, favorable outcomes are attainable. Well-established randomized clinical trials are needed to evaluate the efficacy and safety of using corticosteroids in this condition.

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    APA: Copy

    Kamarullah, William, Nurcahyani, -, Josephine, Claudia Mary, Multazam, Rachmatu Bill, & Nawing, Aqila Ghaezany. (2021). Corticosteroid Therapy in Management of Myocarditis Associated with COVID-19; a Systematic Review of Current Evidence. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 9(1), 0-0. SID. https://sid.ir/paper/783417/en

    Vancouver: Copy

    Kamarullah William, Nurcahyani -, Josephine Claudia Mary, Multazam Rachmatu Bill, Nawing Aqila Ghaezany. Corticosteroid Therapy in Management of Myocarditis Associated with COVID-19; a Systematic Review of Current Evidence. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/783417/en

    IEEE: Copy

    William Kamarullah, - Nurcahyani, Claudia Mary Josephine, Rachmatu Bill Multazam, and Aqila Ghaezany Nawing, “Corticosteroid Therapy in Management of Myocarditis Associated with COVID-19; a Systematic Review of Current Evidence,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/783417/en

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