L-ASPARGINASE EFFECT WITH 6000U/M2 ON LIPID PROFILE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

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ARZANIAN M.T.; EGHBALI A.; ALAVI SAMIN; SHAMSIAN B.SH.; MALEK FATEMEH; AZARGASHB E.A.

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Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2009 | Volume:6 | Issue:2 (23) Page(s): 85-93

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Title

L-ASPARGINASE EFFECT WITH 6000U/M2 ON LIPID PROFILE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Author(s)

Keywords

LEUKEMIAQ3

LYMPHOBLASTICQ3

ACUTEQ2

L-ASPARAGINEQ2

CHILDRENQ2

Abstract

Background and objectives: One of the major etiologies of lipid disorders in malignancies is the use of chemotherapy drugs, the most important of which is L-Asparginase. Studies in different centers with high dosages of L-Asparginase demonstrated different results. The aim of this study is to evaluate the effect of L-Asparginase at a dose of 6000 U/m2 on lipid profile in Iranian CHILDREN with newly diagnosed ACUTE LYMPHOBLASTIC LEUKEMIA in Mofid CHILDREN Hospital of Tehran.Materials and Methods: We performed a nonrandomized trial in which all CHILDREN with newly diagnosed ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) aged <15 years participated. Every case serves as his/her own control. The cholesterol, triglyceride (TG), HDL, LDL, VLDL, APOA, APOB and LPa were evaluated in three stages: before, during and 2 months after treatment with L-Asparginase after which the results were compared.Results: In our study, 82 newly ALL diagnosed patients with the mean age of 6 years (within the age range of 0.12-14 and SD of 3.5) were evaluated. Mean seum level of TG in pretreatment stage was 163.9 mg% and during treatment with L-Asparginase 123 mg% demonstrating significant decline in TG serum level after administration of L-Asparginase (p=0.002). Mean serum level of cholesterol before administration of L-Asparginase was 151mg% and during treatment 140 showing no statistically significant difference (p= 0.061). LPa level in pretreatment phase was 24mg% and during treatment 14 showing a statistically significant difference (p= 0.0001).Conclusions: L-Aspar resulted in decline in TG serum level and increase in HDL though with no significant difference in cholesterol level. Overall, L-Asparginase even at a dose of 6000U/M2 does not raise blood level of triglyceride and cholesterol.

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APA: Copy

ARZANIAN, M.T., EGHBALI, A., ALAVI, SAMIN, SHAMSIAN, B.SH., MALEK, FATEMEH, & AZARGASHB, E.A.. (2009). L-ASPARGINASE EFFECT WITH 6000U/M² ON LIPID PROFILE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 6(2 (23)), 85-93. SID. https://sid.ir/paper/78351/en

Vancouver: Copy

ARZANIAN M.T., EGHBALI A., ALAVI SAMIN, SHAMSIAN B.SH., MALEK FATEMEH, AZARGASHB E.A.. L-ASPARGINASE EFFECT WITH 6000U/M² ON LIPID PROFILE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2009;6(2 (23)):85-93. Available from: https://sid.ir/paper/78351/en

IEEE: Copy

M.T. ARZANIAN, A. EGHBALI, SAMIN ALAVI, B.SH. SHAMSIAN, FATEMEH MALEK, and E.A. AZARGASHB, “L-ASPARGINASE EFFECT WITH 6000U/M² ON LIPID PROFILE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 6, no. 2 (23), pp. 85–93, 2009, [Online]. Available: https://sid.ir/paper/78351/en

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