Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis

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REZAEI TAVIRANI MOSTAFA; ROSTAMI NEJAD MOHAMMAD; ARJMAND BABAK; Rezaei Tavirani Sina; RAZZAGHI MOHAMMADREZA; MANSOURI VAHID

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Journal: Archives of Academic Emergency Medicine Year:2021 | Volume:9 | Issue:1 Page(s): 0-0

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Title

Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis

Author(s)

Keywords

SARS-CoV-2

Proteomics

Proteins

Protein InteractionMaps

Fibrinogen

Abstract

Introduction: Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients’ plasma Proteins have revealed new information about the disease. Introducing the key targeted plasma protein in fatal conditions of COVID-19 infection is the aim of this study. Methods: Significant differentially expressed Proteins (DEPs) in the plasma of cases with a fatal condition of COVID-19 were extracted from an original article. These Proteins were included in a network via STRING database along with 100 first neighbor Proteins to determine central nodes of the network for analyzing. Results: Queried and added Proteins were included in a scale free network. Three hub nodes were identified as critical target Proteins. The top queried hub Proteins were chains of Fibrinogen; Fibrinogen Alpha chain (FGA), Fibrinogen gamma chain (FGG), and Fibrinogen beta chain (FGB), which are related to the coagulation process. Conclusion: It seems that Fibrinogen dysregulation has a deep impact on the fatality of COVID-19 infection.

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APA: Copy

REZAEI TAVIRANI, MOSTAFA, ROSTAMI NEJAD, MOHAMMAD, ARJMAND, BABAK, Rezaei Tavirani, Sina, RAZZAGHI, MOHAMMADREZA, & MANSOURI, VAHID. (2021). Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 9(1), 0-0. SID. https://sid.ir/paper/783897/en

Vancouver: Copy

REZAEI TAVIRANI MOSTAFA, ROSTAMI NEJAD MOHAMMAD, ARJMAND BABAK, Rezaei Tavirani Sina, RAZZAGHI MOHAMMADREZA, MANSOURI VAHID. Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/783897/en

IEEE: Copy

MOSTAFA REZAEI TAVIRANI, MOHAMMAD ROSTAMI NEJAD, BABAK ARJMAND, Sina Rezaei Tavirani, MOHAMMADREZA RAZZAGHI, and VAHID MANSOURI, “Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/783897/en

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