CARRIER DETECTION OF HEMOPHILIA A IN SOUTHERN KHORASAN USING THE 3 POLYMORPHIC SITES OF BCLI, HINDIII, AND ALWNI

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ABBASZADEGAN M.R.; ZIAEI MASOUD; KHADIVIZAND F.; BADIEI Z.; KHAZAEI B.; VAHEDIAN Z.; MEHRABIAN F.; DADKHAH E.

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Journal: The Scientific Journal of Iranian Blood Transfusion Year:2007 | Volume:3 | Issue:4 Page(s): 291-298

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Title

CARRIER DETECTION OF HEMOPHILIA A IN SOUTHERN KHORASAN USING THE 3 POLYMORPHIC SITES OF BCLI, HINDIII, AND ALWNI

Author(s)

Keywords

HEMOPHILIA AQ4

RFLP (RESTRICTION FRAGMENT LENGTH POLYMORPHISM)Q3

CARRIER DETECTIONQ4

Abstract

Background and Objectives: HEMOPHILIA A is the most common X-linked blood coagulation disorder. The prevalence rate of this disease in various communities is about 1-2/10000 males. The prevalence of HEMOPHILIA A is very high in southern Khorasan population, perhaps due to their isolation and high rate of consanguinity. The aim of this research was to detect HEMOPHILIA A carriers in two villages of southern Khorasan and set a prenatal diagnosis program for these families.Materials and Methods: Blood samples of 34 patients with HEMOPHILIA A out of 51 family members (9 families) from two villages were collected. We were also able to collect samples from 7 mothers out of 9 families. Intragenic polymorphic sites in factor VIII gene including HindIII, Bc1I and AlwNI were used for CARRIER DETECTION. DNA extraction and PCR-RELP were also performed.Results: The results revealed 3 heterozygote mothers for HindIII, 2 for Bc1I and 1 for AlwNI. We utilized these polymorphic sites for carrier analysis in these families. Ultimately, 4 carrier sisters of affected boys in this population were found; it was then possible to perform prenatal diagnosis procedure for their families.Conclusions: HindIII and Bc1I polymorphisms can be suitable markers for hemophilia prenatal diagnosis in these two villages.

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References

IDENTIFICATION OF HAEMOPHILIA A CARRIERS DUE TO MUTATION AT INTRON 18 AND 19 OF HEMOPHILIA GENE BY RFLP/PCR METHOD IN WEST. AZERBAIJAN PROVINCE

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APA: Copy

ABBASZADEGAN, M.R., ZIAEI, MASOUD, KHADIVIZAND, F., BADIEI, Z., KHAZAEI, B., VAHEDIAN, Z., MEHRABIAN, F., & DADKHAH, E.. (2007). CARRIER DETECTION OF HEMOPHILIA A IN SOUTHERN KHORASAN USING THE 3 POLYMORPHIC SITES OF BCLI, HINDIII, AND ALWNI. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 3(4), 291-298. SID. https://sid.ir/paper/78401/en

Vancouver: Copy

ABBASZADEGAN M.R., ZIAEI MASOUD, KHADIVIZAND F., BADIEI Z., KHAZAEI B., VAHEDIAN Z., MEHRABIAN F., DADKHAH E.. CARRIER DETECTION OF HEMOPHILIA A IN SOUTHERN KHORASAN USING THE 3 POLYMORPHIC SITES OF BCLI, HINDIII, AND ALWNI. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2007;3(4):291-298. Available from: https://sid.ir/paper/78401/en

IEEE: Copy

M.R. ABBASZADEGAN, MASOUD ZIAEI, F. KHADIVIZAND, Z. BADIEI, B. KHAZAEI, Z. VAHEDIAN, F. MEHRABIAN, and E. DADKHAH, “CARRIER DETECTION OF HEMOPHILIA A IN SOUTHERN KHORASAN USING THE 3 POLYMORPHIC SITES OF BCLI, HINDIII, AND ALWNI,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 3, no. 4, pp. 291–298, 2007, [Online]. Available: https://sid.ir/paper/78401/en

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