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Information Journal Paper

Title

Substituted Urea Herbicide (Diuron) Induced Haemolytic Anemia: A Case of Unknown Complication in Humans

Author(s)

 SUNETH WEERASINGHE WEERASINGHAGE | GAWARAMMANA INDIKA BANDARA | COLAMBAGE ANURADHA | Issue Writer Certificate 

Pages

  136-139

Abstract

 Background: Substituted Urea Herbicide is widely used in the agricultural industry and is accessible to most people around the globe. Accidental or deliberate poisoning is an anticipated complication of these agrochemical products. Case presentation: We present a 15-year-old girl following deliberate self-ingestion of Substituted Urea Herbicide (Diuron). She was diagnosed with Diuron induced Methemoglobinemia and treated with intravenous methylene blue. Later she developed hemolytic anemia and needed 3 units of blood transfusions. Her haemolysis was thought to be due to methylene blue with concomitant Glucose‐ 6‐ phosphate dehydrogenase (G6PD) deficiency as no other possible cause was found for haemolysis. But on follow-up visits, G6PD Deficiency was excluded by the screening test and enzyme level assay. Conclusion: Heamolytic anemia is a possible rare complication that should be anticipated in patients presented with a significant amount of Substituted Urea Herbicide poisoning. Studies have found the possibility of reactive oxygen species accumulation in cells leading to oxidative damage. But we were unable to find any reported cases of haemolysis in humans. We postulate that the inhibition of NADPH production like G6PD Deficiency may be the key mechanism that causes haemolysis in humans by creating an acquired G6PD Deficiency status in red blood cells. However, further studies are needed to identify the exact mechanism of hemolysis in humans.

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    APA: Copy

    SUNETH WEERASINGHE, WEERASINGHAGE, GAWARAMMANA, INDIKA BANDARA, & COLAMBAGE, ANURADHA. (2019). Substituted Urea Herbicide (Diuron) Induced Haemolytic Anemia: A Case of Unknown Complication in Humans. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), 8(4), 136-139. SID. https://sid.ir/paper/784197/en

    Vancouver: Copy

    SUNETH WEERASINGHE WEERASINGHAGE, GAWARAMMANA INDIKA BANDARA, COLAMBAGE ANURADHA. Substituted Urea Herbicide (Diuron) Induced Haemolytic Anemia: A Case of Unknown Complication in Humans. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT)[Internet]. 2019;8(4):136-139. Available from: https://sid.ir/paper/784197/en

    IEEE: Copy

    WEERASINGHAGE SUNETH WEERASINGHE, INDIKA BANDARA GAWARAMMANA, and ANURADHA COLAMBAGE, “Substituted Urea Herbicide (Diuron) Induced Haemolytic Anemia: A Case of Unknown Complication in Humans,” ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), vol. 8, no. 4, pp. 136–139, 2019, [Online]. Available: https://sid.ir/paper/784197/en

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