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Information Journal Paper

Title

EXPRESSION ANALYSIS OF SURVIVIN GENE IN ACUTE PROMYELOCYTIC LEUKEMIA AT DIAGNOSIS AND AFTER TREATMENT

Pages

  10-19

Abstract

 Background and Objectives: Survivin (SVV) is an inhibitor of apoptosis. Its expression rises in most cancer types and is associated with resistance to chemotherapy, increased RECURRENCE, and decreased patient survival. In this study, the expression of SVV gene was analyzed in APL(Acute PROMYELOCYTIC LEUKEMIA) patients.Materials and Methods: In this case-control study, the blood samples of 50 patients were collected in three groups; diagnosis, remission, and RECURRENCE. Then, SVV gene expression was studied using absolute quantitative real time PCR. The data were analysed with SPSS version 17, Kruskal-Wallis and Tukey tests.Results: For the first time, this study demonstrated that SVV overexpressed significantly in APL patients compared with the control (Mean ± SD; 910.5 ± 699) (p <0.01). This overexpression was seen both in diagnosis (4981.4 ± 4112.2) and RECURRENCE groups (4584.2 ± 5133.6) (both p<0.01). After ARSENIC TRIOXIDE therapy (ATO) the SVV expression declined significantly as compared to the diagnosis group (p<0.01).Conclusions: Findings indicate that SVV may have a role in survival of APL cells and induction of apoptosis by decreasing SVV expression can be a probable mechanism of ATO. This study indicates that the SVV may be used as a biomarker in APL patients during the course of the disease.

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    APA: Copy

    NOURI DALOUYI, M.R., ZAKI DIZAJI, M., KHAVANDI, S., ROSTAMI, SH., YESERI, M., ALIMOGHADDAM, K., GHAVAMZADEH, A., & GHAFFARI, S.H.. (2011). EXPRESSION ANALYSIS OF SURVIVIN GENE IN ACUTE PROMYELOCYTIC LEUKEMIA AT DIAGNOSIS AND AFTER TREATMENT. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 8(1 (30)), 10-19. SID. https://sid.ir/paper/78421/en

    Vancouver: Copy

    NOURI DALOUYI M.R., ZAKI DIZAJI M., KHAVANDI S., ROSTAMI SH., YESERI M., ALIMOGHADDAM K., GHAVAMZADEH A., GHAFFARI S.H.. EXPRESSION ANALYSIS OF SURVIVIN GENE IN ACUTE PROMYELOCYTIC LEUKEMIA AT DIAGNOSIS AND AFTER TREATMENT. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2011;8(1 (30)):10-19. Available from: https://sid.ir/paper/78421/en

    IEEE: Copy

    M.R. NOURI DALOUYI, M. ZAKI DIZAJI, S. KHAVANDI, SH. ROSTAMI, M. YESERI, K. ALIMOGHADDAM, A. GHAVAMZADEH, and S.H. GHAFFARI, “EXPRESSION ANALYSIS OF SURVIVIN GENE IN ACUTE PROMYELOCYTIC LEUKEMIA AT DIAGNOSIS AND AFTER TREATMENT,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 8, no. 1 (30), pp. 10–19, 2011, [Online]. Available: https://sid.ir/paper/78421/en

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