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Information Journal Paper

Title

Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells

Pages

  0-0

Keywords

EMT 
1 

Abstract

 Background: Mummy (Iranian pure shilajit) is a remedy with possessing anti-inflammatory, antioxidant and anticancer activities. This study aimed to examine Mummy effects on epithelial-mesenchymal transition (EMT) and invasiveness of MCF-7 and MDA-MB-231 Breast Cancer (BC) cell lines with underlying its mechanism. Materials and Methods: The dose-dependent inhibitory effect of the Mummy on cell proliferation in vitro was determined using the MTT assay. Flow cytometry and 4’ , 6-diamidino-2-phenylindole dihydrochloride staining were respectively used for quantitative and qualitative analysis of cellular Apoptosis, and gene expression analysis was conducted using real-time PCR. Results: MDA-MB-231 showed more sensitivity than the MCF-7 cell line to the anticancer activity of Mummy, while Mummy did not exhibit significant cell cytotoxicity against human normal cells (MCF-10A). The gene expression profile demonstrated a significant decrease in TGF-β 1, TGF-β R1, TWIST1, NOTCH1, CTNNB1, SRC along with an increase in E-cadherin mRNA levels in Mummy treated cells compared to the untreated control group (P≤ 0. 05). Conclusion: Mummy triggers inhibition of EMT and metastasis in Breast Cancer cells mainly through the downregulation of TGFβ; 1 activity, and more studies required to find its specific anticancer activity with details.

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References

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APA: Copy

Rahmani Barouji, Solmaz, Shahabi, Arman, TORBATI, MOHAMMADALI, Fazljou, Seyyed Mohammad Bagher, & Yari Khosroushahi, Ahmad. (2020). Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells. GALEN MEDICAL JOURNAL, 9(1), 0-0. SID. https://sid.ir/paper/784306/en

Vancouver: Copy

Rahmani Barouji Solmaz, Shahabi Arman, TORBATI MOHAMMADALI, Fazljou Seyyed Mohammad Bagher, Yari Khosroushahi Ahmad. Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells. GALEN MEDICAL JOURNAL[Internet]. 2020;9(1):0-0. Available from: https://sid.ir/paper/784306/en

IEEE: Copy

Solmaz Rahmani Barouji, Arman Shahabi, MOHAMMADALI TORBATI, Seyyed Mohammad Bagher Fazljou, and Ahmad Yari Khosroushahi, “Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells,” GALEN MEDICAL JOURNAL, vol. 9, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/784306/en

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