CELLULAR AND MOLECULAR ASPECTS OF MULTIPLE MYELOMA

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ABROUN S.; SAKI N.A.D.

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Paper Information

Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2010 | Volume:7 | Issue:3 (28) Page(s): 183-195

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Title

CELLULAR AND MOLECULAR ASPECTS OF MULTIPLE MYELOMA

Author(s)

ABROUN S. | SAKI N.A.D. | Issue Writer Certificate

Keywords

MULTIPLE MYELOMAQ3

OSTEOCLASTQ3

OSTEOBLASTSQ3

Abstract

Background and Objectives: MULTIPLE MYELOMA (MM) is a plasma cell disorder which accounts for about 10% of all hematologic cancers; 99% of patients diagnosed are older than 40 years of age. The aim of this study is to evaluate the recognized cellular and molecular factors effective on the emergence and development of MM.Materials and Methods: In the present study, 150 articles about genetic translocation, OSTEOCLAST and osteoblast cells, chemokines, signaling pathways, and MULTIPLE MYELOMA published in recent years were firstly selected to be reviewed. Out of this number, 69 which applied to cellular and molecular biology of MM were selected to be studied.Results: Bone lesions and pathological fractures are the most important complications of MULTIPLE MYELOMA. Recurrent infection, renal insufficiency, hyperproteinemia, amyloidosis, hypercalcemia, decrease of alkaline phosphatase, and osteocalcin are other complications which are mostly caused by cell-cell interaction, chemokine, and immunoglobulin signal induction.Conclusions: The results show that infiltration of tumor cells like myeloma cells is due to secretion of some factors from BM cells as well as the presence of calcium and iron whose concentration is high in BM.

Cites

STATS: AN OLD STORY, YET MESMERIZING

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APA: Copy

ABROUN, S., & SAKI, N.A.D.. (2010). CELLULAR AND MOLECULAR ASPECTS OF MULTIPLE MYELOMA. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 7(3 (28)), 183-195. SID. https://sid.ir/paper/78461/en

Vancouver: Copy

ABROUN S., SAKI N.A.D.. CELLULAR AND MOLECULAR ASPECTS OF MULTIPLE MYELOMA. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2010;7(3 (28)):183-195. Available from: https://sid.ir/paper/78461/en

IEEE: Copy

S. ABROUN, and N.A.D. SAKI, “CELLULAR AND MOLECULAR ASPECTS OF MULTIPLE MYELOMA,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 7, no. 3 (28), pp. 183–195, 2010, [Online]. Available: https://sid.ir/paper/78461/en

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