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Information Journal Paper

Title

Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats

Pages

  85-93

Abstract

 Aims: Burn infections are one of the most common causes of mortality in the world. On the other hand, microbial resistance to antibiotics has caused concern in the medical community. Therefore, controlling Burn infections is very important, and using alternative therapies instead of antibiotics could be a good solution to this problem. Materials & Methods: Lactobacillus plantarum 299v strains were used in the experiments. Fifty male Wistar rats were prepared, and Burn was induced in animals. The Burn wounds were inoculated with clinical strains of MDR Pseudomonas aeruginosa in all animals and then treated daily with an eucerin ointment containing different compositions, including NaCl, Imipenem, probiotic cell pellet, probiotic supernatant, and probiotic cell pellet + probiotic supernatant. The Wound healing process was evaluated in animals after 7 days of treatment. Comparisons between different groups were performed using One-way ANOVA and Turkey’ s post hoc tests. Findings: After 7 days of treatment, the mean wound size in the probiotic cell pellet group was significantly lower than in the control and Imipenem groups. Also, the mean wound size in the probiotic supernatant group was significantly lower than in the Imipenem group. Histological parameters related to skin repair in the probiotic cell pellet group was better than in the control and antibiotic groups. Also, inflammation in the probiotic cell pellet group was less than in the control and Imipenem groups. Conclusion: The macroscopic results of this study supported the microscopic results and showed that the mean size of the Burn wounds in the probiotic cell pellet group was less than in the control and Imipenem groups after 7 days of treatment.

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    APA: Copy

    Soleymanzadeh Moghadam, Somayeh, Mousavi Shabestari, Tahereh, HEIDARI, FATEMEH, RASOULI KOOHI, SAMIRA, AFSHAR, MASTANEH, Omranian, Roya, & NOBAKHT, MALIHEH. (2020). Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), 6(2), 85-93. SID. https://sid.ir/paper/785119/en

    Vancouver: Copy

    Soleymanzadeh Moghadam Somayeh, Mousavi Shabestari Tahereh, HEIDARI FATEMEH, RASOULI KOOHI SAMIRA, AFSHAR MASTANEH, Omranian Roya, NOBAKHT MALIHEH. Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE)[Internet]. 2020;6(2):85-93. Available from: https://sid.ir/paper/785119/en

    IEEE: Copy

    Somayeh Soleymanzadeh Moghadam, Tahereh Mousavi Shabestari, FATEMEH HEIDARI, SAMIRA RASOULI KOOHI, MASTANEH AFSHAR, Roya Omranian, and MALIHEH NOBAKHT, “Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats,” INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), vol. 6, no. 2, pp. 85–93, 2020, [Online]. Available: https://sid.ir/paper/785119/en

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