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Title

Exon 2 Vitamin D Receptor (Fok-I) Gene Polymorphism and the Evaluation of its Correlation With Renal Dysfunction in Patients With β-Thalassemia Major in East Azerbaijan Province of Iran

Pages

  393-397

Abstract

 Objectives: Several studies have shown that major beta-Thalassemia patients suffer from renal dysfunction. Genetic is one of the crucial factors in this phenomenon. Accordingly, this study aimed to evaluate the correlation between renal dysfunction and Fok-I polymorphism in the Vitamin D receptor (VDR) gene of major beta-Thalassemia patients. Materials and Methods: Sixty thalassemic patients and sixty healthy individuals were involved in this case-control study. Robust renal and urine analyzes were done in terms of performance evaluation. Finally, genotype assessment for Fok-I polymorphism was performed via the polymerase chain reaction-restriction fragment length polymorphism method. Results: In general, renal dysfunction embracing proteinuria and hyperfilteration were observed in the thalassemic group. As regards patients’ genotype frequencies, 51. 6%, 36. 6%, and 11. 6% were homozygous for F allele (FF), heterozygous (Ff), and homozygous for f allele (ff), respectively. Eventually, the frequencies of FF and Ff alleles were 49. 1% and 50. 8%, respectively, in normal group l. Conclusions: Our data suggested that there is no correlation between renal dysfunction and Fok-I polymorphism in major beta-thalassemic patients. Thus, further studies are needed about plausible pathways involved in renal dysfunction, to demonstrate the motives of renal dysfunction in major beta-Thalassemia patients.

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    APA: Copy

    Najafpour, Malihe, FARSHDOUSTI HAGH, MAJID, Azimi, Ako, ZADI HEYDARABAD, MILAD, Balekdari, Peyman, Jahanban Esfahlan, Aylin, GHASEMI, AMIN, & Ganbarjeddi, Saiedeh. (2020). Exon 2 Vitamin D Receptor (Fok-I) Gene Polymorphism and the Evaluation of its Correlation With Renal Dysfunction in Patients With β-Thalassemia Major in East Azerbaijan Province of Iran. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, 7(3), 393-397. SID. https://sid.ir/paper/785198/en

    Vancouver: Copy

    Najafpour Malihe, FARSHDOUSTI HAGH MAJID, Azimi Ako, ZADI HEYDARABAD MILAD, Balekdari Peyman, Jahanban Esfahlan Aylin, GHASEMI AMIN, Ganbarjeddi Saiedeh. Exon 2 Vitamin D Receptor (Fok-I) Gene Polymorphism and the Evaluation of its Correlation With Renal Dysfunction in Patients With β-Thalassemia Major in East Azerbaijan Province of Iran. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES[Internet]. 2020;7(3):393-397. Available from: https://sid.ir/paper/785198/en

    IEEE: Copy

    Malihe Najafpour, MAJID FARSHDOUSTI HAGH, Ako Azimi, MILAD ZADI HEYDARABAD, Peyman Balekdari, Aylin Jahanban Esfahlan, AMIN GHASEMI, and Saiedeh Ganbarjeddi, “Exon 2 Vitamin D Receptor (Fok-I) Gene Polymorphism and the Evaluation of its Correlation With Renal Dysfunction in Patients With β-Thalassemia Major in East Azerbaijan Province of Iran,” CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, vol. 7, no. 3, pp. 393–397, 2020, [Online]. Available: https://sid.ir/paper/785198/en

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