مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Effect of amitriptyline on orthodontic tooth movement in rats: an experimental study

Pages

  147-152

Abstract

 Background. Orthodontic tooth movement (OTM) occurs in the alveolar bone; therefore, any condition affecting bone quality can alter OTM. This study aimed to evaluate the effect of Amitriptyline on OTM in Rats. Methods. Forty-five male Wistar Rats were randomly divided into three groups: (I) no injection, (II) injection with saline solution, and (III) injection of Amitriptyline. Next, a-60gr force was applied to the maxillary left first molar tooth of all the Rats, using a nickel‒ titanium closed-coil spring ligated between the maxillary incisors and the left first molar tooth. The Rats were sacrificed after 21 days to measure OTM and perform histological analysis to determine the number, width, and depth of resorptive lacunae, osteoclast counts, and periodontal ligament (PDL) width. Results. The highest and the lowest OTM rates were found in the control and Amitriptyline groups, respectively; however, there was no significant difference between the study groups in this regard. Histological analysis showed a significantly lower number of resorption lacunae in the Amitriptyline group than the saline group. Conclusion. Although no significant difference was noted in OTM after Amitriptyline administration, a reduction in the number of resorptive lacunae in Rats injected with Amitriptyline suggests that Amitriptyline affects the bone tissue at the cellular level.

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    Cite

    APA: Copy

    Akhoundi, Mohammad Sadegh Ahmad, Shaygan Mehr, Mahdiyeh, Keshvad, Mohammad Ali, Etemad Moghaddam, Shahroo, ALAEDDINI, MOJGAN, DEHPOUR, AHMADREZA, & MIRHASHEMI, AMIR HOSSEIN. (2020). Effect of amitriptyline on orthodontic tooth movement in rats: an experimental study. JOURNAL OF DENTAL RESEARCH, DENTAL CLINICS, DENTAL PROSPECTS, 14(3), 147-152. SID. https://sid.ir/paper/785354/en

    Vancouver: Copy

    Akhoundi Mohammad Sadegh Ahmad, Shaygan Mehr Mahdiyeh, Keshvad Mohammad Ali, Etemad Moghaddam Shahroo, ALAEDDINI MOJGAN, DEHPOUR AHMADREZA, MIRHASHEMI AMIR HOSSEIN. Effect of amitriptyline on orthodontic tooth movement in rats: an experimental study. JOURNAL OF DENTAL RESEARCH, DENTAL CLINICS, DENTAL PROSPECTS[Internet]. 2020;14(3):147-152. Available from: https://sid.ir/paper/785354/en

    IEEE: Copy

    Mohammad Sadegh Ahmad Akhoundi, Mahdiyeh Shaygan Mehr, Mohammad Ali Keshvad, Shahroo Etemad Moghaddam, MOJGAN ALAEDDINI, AHMADREZA DEHPOUR, and AMIR HOSSEIN MIRHASHEMI, “Effect of amitriptyline on orthodontic tooth movement in rats: an experimental study,” JOURNAL OF DENTAL RESEARCH, DENTAL CLINICS, DENTAL PROSPECTS, vol. 14, no. 3, pp. 147–152, 2020, [Online]. Available: https://sid.ir/paper/785354/en

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