THE PREVALENCE OF PLATELET FUNCTION DEFECTS IN PATIENTS REFERRED TO THE SPECIAL REFERENCE COAGULATION LABORATORY OF IRANIAN BLOOD TRANSFUSION ORGANIZATION

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RAJABI A.; AHMADINEJAD M.; MASHKOOLI M.; TABATABAEI S.M.R.; SEYED MORTAZ S.L.; RAN BALOOCH S.; MOAZEZI NEKOUI ASL S.S.; MOKHTARI Z.; MOJTABAVI NAEINI M.

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Journal: The Scientific Journal of Iranian Blood Transfusion Year:2014 | Volume:11 | Issue:1 (43) Page(s): 23-31

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Title

THE PREVALENCE OF PLATELET FUNCTION DEFECTS IN PATIENTS REFERRED TO THE SPECIAL REFERENCE COAGULATION LABORATORY OF IRANIAN BLOOD TRANSFUSION ORGANIZATION

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Keywords

BLOOD PLATELET DISORDERSQ2

PLATELET FUNCTION TESTSQ2

PLATELET AGGREGATIONQ3

BERNARD-SOULIER SYNDROMEQ2

THROMBASTHENIAQ2

Abstract

Background and Objectives Platelet function disorders are common in the world population but in our country except for severe cases, they are not well investigated due to limited diagnostic tools. In recent two years we aimed to assess PLATELET FUNCTION TESTS in referral patients suspected of platelet function disorders, in the special reference coagulation laboratory of Iranian Blood Transfusion Organization, as the center equipped with lumi-aggregometer.Materials and Methods We have investigated 195 referral patients during a seven-month period, from November 2011 to May 2012, for PLATELET AGGREGATION and ATP release response for highly suspected patients with four platelet agonists ADP, collagen, arachidonic acid and ristocetin and a luciferinluciferase reagent. Results were analyzed by SPSS version 16.Results Among 195 referred patients, 90 cases (46.1%) had an abnormality in platelet count or function. Abnormal cases fall within the categories of low platelet count with normal function (8.2%), ATP release (secretion) defect (6.7%), Glanzman's thrombastenia (4.6%), Bernard Solier Syndrome (2%), acquired platelet defect (1.5%), afibrinogenemia (0.5%), and uncategorized platelet function disorders (22.6%). The other 105 remaining patients showed a quiet normal result.Conclusions The present study is the first simultaneous analysis of platelet function and secretion disorders.In order to guess the true prevalence of these disorders, more wider and comprehensive studies, the use of more complete panels of agonists and ATP release assessment in all patients with an abnormal aggregometry pattern have been suggested for future studies.

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APA: Copy

RAJABI, A., AHMADINEJAD, M., MASHKOOLI, M., TABATABAEI, S.M.R., SEYED MORTAZ, S.L., RAN BALOOCH, S., MOAZEZI NEKOUI ASL, S.S., MOKHTARI, Z., & MOJTABAVI NAEINI, M.. (2014). THE PREVALENCE OF PLATELET FUNCTION DEFECTS IN PATIENTS REFERRED TO THE SPECIAL REFERENCE COAGULATION LABORATORY OF IRANIAN BLOOD TRANSFUSION ORGANIZATION. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 11(1 (43)), 23-31. SID. https://sid.ir/paper/78556/en

Vancouver: Copy

RAJABI A., AHMADINEJAD M., MASHKOOLI M., TABATABAEI S.M.R., SEYED MORTAZ S.L., RAN BALOOCH S., MOAZEZI NEKOUI ASL S.S., MOKHTARI Z., MOJTABAVI NAEINI M.. THE PREVALENCE OF PLATELET FUNCTION DEFECTS IN PATIENTS REFERRED TO THE SPECIAL REFERENCE COAGULATION LABORATORY OF IRANIAN BLOOD TRANSFUSION ORGANIZATION. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2014;11(1 (43)):23-31. Available from: https://sid.ir/paper/78556/en

IEEE: Copy

A. RAJABI, M. AHMADINEJAD, M. MASHKOOLI, S.M.R. TABATABAEI, S.L. SEYED MORTAZ, S. RAN BALOOCH, S.S. MOAZEZI NEKOUI ASL, Z. MOKHTARI, and M. MOJTABAVI NAEINI, “THE PREVALENCE OF PLATELET FUNCTION DEFECTS IN PATIENTS REFERRED TO THE SPECIAL REFERENCE COAGULATION LABORATORY OF IRANIAN BLOOD TRANSFUSION ORGANIZATION,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 11, no. 1 (43), pp. 23–31, 2014, [Online]. Available: https://sid.ir/paper/78556/en

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