MINI-POOL SCREENING FOR HCV INFECTION IN IRANIAN BLOOD DONORS: PRELIMINARY RESULTS

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AMINI KAFIABAD S.; TALEBIAN A.; RANJBAR KERMANI F.; MOGHTADAEI M.; SOBHANI MARYAM; SAMIEI SH.

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Journal: The Scientific Journal of Iranian Blood Transfusion Year:2005 | Volume:2 | Issue:3 Page(s): 13-21

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Information Journal Paper

Title

MINI-POOL SCREENING FOR HCV INFECTION IN IRANIAN BLOOD DONORS: PRELIMINARY RESULTS

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Keywords

BLOOD DONATIONQ4

DONOR SCREENINGQ3

HEPATITIS C VIRUSQ3

PLASMAQ3

POOLEDQ4

PCRQ4

Abstract

Background and Objectives Screening the blood donors for serological markers reduced the incidence of transfusiontransmitted infections especially post-transfusion hepatitis C. However, there remains residual risk due to pre-seroconversion period. HCV RNA (PCR) of BLOOD DONATIONs reduced the residual risk of transfusion-transmitted HCV infection. In this study, BLOOD DONATIONs were screened for HCV RNA by RT-PCR method.Materials and MethodsAn extra PLASMA sample was collected from 1026 blood donors. 1000 out of 1026 samples were negative for HBsAg, anti-HCV (EIA, third generation), anti-HIV and RPR. Every 5 samples were POOLED. The sensitivity of HCV-RNA detection by RT-PCR method was 380 geq/ml according to Proficiency VQC panel. 1000 donations in 200 pools were tested.ResultsFalse reactivity of samples considered positive accounts for 5.5% of cases, and 5.5% were invalid due to non-specilic bands. 6% of the pools were false-positive. A false positive result was defined as positive on initial testing but negative on repeat single testing. However, all of the samples were negative for HCV RNA by RT-PCR method.ConclusionsNo sample was found to be serologically negative and HCV RNA positive. However, further studies are recommended for further clarification.

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APA: Copy

AMINI KAFIABAD, S., TALEBIAN, A., RANJBAR KERMANI, F., MOGHTADAEI, M., SOBHANI, MARYAM, & SAMIEI, SH.. (2005). MINI-POOL SCREENING FOR HCV INFECTION IN IRANIAN BLOOD DONORS: PRELIMINARY RESULTS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 2(3), 13-21. SID. https://sid.ir/paper/78564/en

Vancouver: Copy

AMINI KAFIABAD S., TALEBIAN A., RANJBAR KERMANI F., MOGHTADAEI M., SOBHANI MARYAM, SAMIEI SH.. MINI-POOL SCREENING FOR HCV INFECTION IN IRANIAN BLOOD DONORS: PRELIMINARY RESULTS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2005;2(3):13-21. Available from: https://sid.ir/paper/78564/en

IEEE: Copy

S. AMINI KAFIABAD, A. TALEBIAN, F. RANJBAR KERMANI, M. MOGHTADAEI, MARYAM SOBHANI, and SH. SAMIEI, “MINI-POOL SCREENING FOR HCV INFECTION IN IRANIAN BLOOD DONORS: PRELIMINARY RESULTS,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 2, no. 3, pp. 13–21, 2005, [Online]. Available: https://sid.ir/paper/78564/en

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