THE DIAGNOSTIC VALUE OF CD14 AND CD64 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF MONOID SUBTYPE OF ACUTE MYELOID LEUKEMIA

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NIKOU GOFTAR M.; AGHAEIPOUR M.; TABATABAEIAN A.A.S.; VAELI SH.; FALLAHAZAD V.; MAGHSOUDLOU M.; ATASHRAZM F.

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Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2005 | Volume:2 | Issue:3 Page(s): 1-6

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Title

THE DIAGNOSTIC VALUE OF CD14 AND CD64 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF MONOID SUBTYPE OF ACUTE MYELOID LEUKEMIA

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Keywords

ACUTE LEUKEMIAQ4

FABQ4

IMMUNOPHENOTYPINGQ3

FLOW CYTOMETRYQ4

ACUTE MYELOID LEUKEMIAQ4

ACUTE MONOCYTIC LEUKEMIAQ4

CD14Q4

CD64Q4

Abstract

Background and Objectives Although the French-American-British (FAB) Classification system is the basis for the diagnosis and treatment of AML, it has its own limitations. During recent years IMMUNOPHENOTYPING by FLOW CYTOMETRY is widely used for the identification of AMLS subtypes. IMMUNOPHENOTYPING has been especially helpful in discrimination of AML with monocytic differentiation (M4-M5) from nonmonocytic subtypes (M0- M1- M2- M3- M6- M7). However several studies have indicated that CD14 mostly is negative when applied to leukemias with monocyte differentiation.Materials and MethodsSome studies have shown that CD64 (FCγRI) is an early and specific myelo-monoid marker. In this study we evaluated CD14 and CD64 antibodies to identify cells of monocytic lineage in 216 cases of AML who were referred to IBTO FLOW CYTOMETRY laboratory. These monoclonal antibodies prepared by DAKO Company and were conjugated with Phyco Erythrin. The samples were analysed by Epics-x1 Flow cytometer. The markers were considered positive if 20% or more of the cells expressed it. The Chi-square test was also used in SPSS software.ResultsResults revealed that CD64 was highty specific (88%) and sensitive (67%) and CD14 was highty specific (96%) but not sensitive (31%) with >95% confidence rate. These results are compatible with other studies.ConclusionsFinally because of high sensitivity of CD64, it should be considered in all of IMMUNOPHENOTYPING protocols as a sensitive and specific marker for monoid cells.

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APA: Copy

NIKOU GOFTAR, M., AGHAEIPOUR, M., TABATABAEIAN, A.A.S., VAELI, SH., FALLAHAZAD, V., MAGHSOUDLOU, M., & ATASHRAZM, F.. (2005). THE DIAGNOSTIC VALUE OF CD14 AND CD64 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF MONOID SUBTYPE OF ACUTE MYELOID LEUKEMIA. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 2(3), 1-6. SID. https://sid.ir/paper/78565/en

Vancouver: Copy

NIKOU GOFTAR M., AGHAEIPOUR M., TABATABAEIAN A.A.S., VAELI SH., FALLAHAZAD V., MAGHSOUDLOU M., ATASHRAZM F.. THE DIAGNOSTIC VALUE OF CD14 AND CD64 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF MONOID SUBTYPE OF ACUTE MYELOID LEUKEMIA. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2005;2(3):1-6. Available from: https://sid.ir/paper/78565/en

IEEE: Copy

M. NIKOU GOFTAR, M. AGHAEIPOUR, A.A.S. TABATABAEIAN, SH. VAELI, V. FALLAHAZAD, M. MAGHSOUDLOU, and F. ATASHRAZM, “THE DIAGNOSTIC VALUE OF CD14 AND CD64 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF MONOID SUBTYPE OF ACUTE MYELOID LEUKEMIA,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 2, no. 3, pp. 1–6, 2005, [Online]. Available: https://sid.ir/paper/78565/en

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