RELATIVE SENSITIVITY OF THIRD GENERATION HEPATITIS C VIRUS ANTIBODY DETECTION ASSAYS: EVALUATION OF 20 KITS

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AMINI KAFIABAD S.; TALEBIAN A.; MAGHSOUDLOU M.; RAMAN S.

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Paper Information

Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2005 | Volume:2 | Issue:5 Page(s): 171-181

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Information Journal Paper

Title

RELATIVE SENSITIVITY OF THIRD GENERATION HEPATITIS C VIRUS ANTIBODY DETECTION ASSAYS: EVALUATION OF 20 KITS

Author(s)

AMINI KAFIABAD S. | TALEBIAN A. | MAGHSOUDLOU M. | RAMAN S. | Issue Writer Certificate

Keywords

ANTIBODYQ4

HEPATITIS CQ3

ELISAQ4

SENSITIVITYQ4

SEROCONVERSION PANELQ2

Abstract

Background and Objectives The most important challenge in selecting suitable assays for the detection of anti-HCV is SENSITIVITY. In this study, 20 assays (EIA method) were compared with each other and with anti-HCV 3.0 Enhanced SAV (Ortho Company production) as the reference assay recommended by WHO. Materials and Methods 20 kits were compared by 3 to 4 seroconversion and 2 to 3 performance panels. The relative SENSITIVITY of kits was calculated based on WHO recommendations. Results In SEROCONVERSION PANELs, relative SENSITIVITY of 3 assays was the same as the reference assay and 5 assays showed lower relative SENSITIVITY, but the differences between these five kits and the reference assay appeared just in two samples. In performance panels, two assays came out to be the same as the reference assay and the other 5 assays detected just 2 samples to have a level lower than anti-HCV 3. In all seroconversion and performance panels, the best results were obtained by ETI-AB-HCH-K4 (146) (Diasorin), Monalisa Anti-HCV plus Version 2 (BIO-RAD), Hepanostica Anti-HCV ULTRA (BIOMERIEUX), Anti-HCV-EIA 3rd (Avicenna Medial Center), and HCV AB (DIA PRO). Conclusions For improvement of blood safety, the assay with high SENSITIVITY is recommended to be used, and the samples with weak positive reactions especially in seroconversion and low titer performance panels should be given more attention.

Cites

COMPARISON OF THE POSITIVE PREDICATIVE VALUE OF TWO ENZYME IMMUNOASSAY SCREENING KITS FOR HEPATITIS C IN BLOOD DONORS

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APA: Copy

AMINI KAFIABAD, S., TALEBIAN, A., MAGHSOUDLOU, M., & RAMAN, S.. (2005). RELATIVE SENSITIVITY OF THIRD GENERATION HEPATITIS C VIRUS ANTIBODY DETECTION ASSAYS: EVALUATION OF 20 KITS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 2(5), 171-181. SID. https://sid.ir/paper/78712/en

Vancouver: Copy

AMINI KAFIABAD S., TALEBIAN A., MAGHSOUDLOU M., RAMAN S.. RELATIVE SENSITIVITY OF THIRD GENERATION HEPATITIS C VIRUS ANTIBODY DETECTION ASSAYS: EVALUATION OF 20 KITS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2005;2(5):171-181. Available from: https://sid.ir/paper/78712/en

IEEE: Copy

S. AMINI KAFIABAD, A. TALEBIAN, M. MAGHSOUDLOU, and S. RAMAN, “RELATIVE SENSITIVITY OF THIRD GENERATION HEPATITIS C VIRUS ANTIBODY DETECTION ASSAYS: EVALUATION OF 20 KITS,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 2, no. 5, pp. 171–181, 2005, [Online]. Available: https://sid.ir/paper/78712/en

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