SYNTHESIS AND ANTI-INTRACELLULAR COPPER OVERLOAD EVALUATION OF NANOCONJUGATED D-PENICILLAMINE –DENDRIMER IN WILSON’S MODEL CELLS

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FANI N.; SHAFIEE ARDESTANI M.; YAGHMAEI P.; ASSADI A.; BARZEGAR BEHROUZ A.

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Journal: Journal of Gorgan University of Medical Sciences Year:2016 | Volume:18 | Issue:1 (57) Page(s): 114-119

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Title

SYNTHESIS AND ANTI-INTRACELLULAR COPPER OVERLOAD EVALUATION OF NANOCONJUGATED D-PENICILLAMINE –DENDRIMER IN WILSON’S MODEL CELLS

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WILSON’S DISEASEQ3

NANOCONJUGATED D-PENICILLAMINE-DENDRIMERQ1

Abstract

Background and Objective: WILSON’S DISEASE (WD) is caused by mutation to the cooer-transporting gene ATP7B. Chelation therapy is the main protochol of treatment for patients with WILSON’S DISEASE.D-penicillamine is one of the well-known chelator agants which is used in WD treatment but it can not enter into the intracellular space.This study was done to evaluate the synthesis and anti-intracellular Copper overload evaluation of Nanoconjugated D-penicillamine –Dendrimer in Wilson’s model cells.Methods: In this descriptive-analytic study, initially 0.01 mm polyethylene glycol (PEG) and 0.0018 mm citric acid, Dendrimer was synthesized. After purification by dialysis bag and lyophilization, 10mg dendrimer was conjugated to 3.3mg D-penicillamine. NANOCONJUGATED D-PENICILLAMINE-DENDRIMER was injected on Wilson’s model cells. After incubation and centrifugation intracellular measurement of copper concentration and FTIR test were done.Results: Copper accumulation significantly reduced in the HepG2 WD cell by Nanoconjugated D-penicillamine - Dendrimer in compared to D-penicillamine (P<0.05). Copper accumulation was determined to be 46.61. MTT assay showed no toxicological damage in HepG2 WD cell.Conclusion: Nanoconjugated D-penicillamine –Dendrimer can reduces intracellular concentration of Copper.

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APA: Copy

FANI, N., SHAFIEE ARDESTANI, M., YAGHMAEI, P., ASSADI, A., & BARZEGAR BEHROUZ, A.. (2016). SYNTHESIS AND ANTI-INTRACELLULAR COPPER OVERLOAD EVALUATION OF NANOCONJUGATED D-PENICILLAMINE –DENDRIMER IN WILSON’S MODEL CELLS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 18(1 (57)), 114-119. SID. https://sid.ir/paper/78823/en

Vancouver: Copy

FANI N., SHAFIEE ARDESTANI M., YAGHMAEI P., ASSADI A., BARZEGAR BEHROUZ A.. SYNTHESIS AND ANTI-INTRACELLULAR COPPER OVERLOAD EVALUATION OF NANOCONJUGATED D-PENICILLAMINE –DENDRIMER IN WILSON’S MODEL CELLS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;18(1 (57)):114-119. Available from: https://sid.ir/paper/78823/en

IEEE: Copy

N. FANI, M. SHAFIEE ARDESTANI, P. YAGHMAEI, A. ASSADI, and A. BARZEGAR BEHROUZ, “SYNTHESIS AND ANTI-INTRACELLULAR COPPER OVERLOAD EVALUATION OF NANOCONJUGATED D-PENICILLAMINE –DENDRIMER IN WILSON’S MODEL CELLS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 1 (57), pp. 114–119, 2016, [Online]. Available: https://sid.ir/paper/78823/en

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