EFFECT OF HYDRO-ALCHOLIC EXTRACT OF PIMPINELLA ANISUM SEED ON ANXIETY IN MALE RAT

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NIKSOKHAN M.; HEDARIEH N.; NAJAFIFARD MARYAM; NAJAFIFARD MASOOMEH

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Journal: Journal of Gorgan University of Medical Sciences Year:2015 | Volume:16 | Issue:4 (52) Page(s): 28-33

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Title

EFFECT OF HYDRO-ALCHOLIC EXTRACT OF PIMPINELLA ANISUM SEED ON ANXIETY IN MALE RAT

Author(s)

NIKSOKHAN M. | HEDARIEH N. | NAJAFIFARD MARYAM | NAJAFIFARD MASOOMEH | Issue Writer Certificate

Keywords

ANXIETYQ2

PIMPINELLA ANISUMQ2

MAZE TESTQ3

RATQ2

Abstract

Background and Objective: ANXIETY is a common psychological disorder. This study was carried out to evaluate the effect of hydro-alcholic extract of PIMPINELLA ANISUM seed on ANXIETY in male RAT.Method: In this experimental study, 42 male Wistar RATs, randomly allocated into six groups including: negative control group (no injection), positive control (saline) and experimental groups (receiving doses 100, 200, 250, 300 mg/kg/bw of hydro-alcholic extract of PIMPINELLA ANISUM seed, intraperitoneally).Indices of ANXIETY including time spent in open arms and number of open arm entries were evaluated using elevated plus maze, 30 minutes after injection.Results: At doses of 250 and 300 mg/kg/bw of hydro-alcholic extract of PIMPINELLA ANISUM seed, the time spent in open arms of maze were significantly increased and the time spent in maze close arms were decreased in compared to controls (P<0.05). At dose of 300 mg/kg/bw of PIMPINELLA ANISUM seed extract, number of open arm entries increased in compared to control group (P<0.05). None of the doses showed any significant effect on locomotor activites.Conclusion: Hydro-alcholic extract of PIMPINELLA ANISUM seed with dosage of 250 and 300 mg/kg/bw reduces ANXIETY in male RATs.

Cites

EVALUATION OF ANTIDEPRESSANT-LIKE EFFECTS OF AQUEOUS AND ETHANOLIC EXTRACTS OF PIMPINELLA ANISUM FRUIT IN MICE

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APA: Copy

NIKSOKHAN, M., HEDARIEH, N., NAJAFIFARD, MARYAM, & NAJAFIFARD, MASOOMEH. (2015). EFFECT OF HYDRO-ALCHOLIC EXTRACT OF PIMPINELLA ANISUM SEED ON ANXIETY IN MALE RAT. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 16(4 (52)), 28-33. SID. https://sid.ir/paper/78959/en

Vancouver: Copy

NIKSOKHAN M., HEDARIEH N., NAJAFIFARD MARYAM, NAJAFIFARD MASOOMEH. EFFECT OF HYDRO-ALCHOLIC EXTRACT OF PIMPINELLA ANISUM SEED ON ANXIETY IN MALE RAT. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;16(4 (52)):28-33. Available from: https://sid.ir/paper/78959/en

IEEE: Copy

M. NIKSOKHAN, N. HEDARIEH, MARYAM NAJAFIFARD, and MASOOMEH NAJAFIFARD, “EFFECT OF HYDRO-ALCHOLIC EXTRACT OF PIMPINELLA ANISUM SEED ON ANXIETY IN MALE RAT,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 4 (52), pp. 28–33, 2015, [Online]. Available: https://sid.ir/paper/78959/en

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