PROTECTIVE EFFECTS OF DESMOPRESSIN ACETATE ON RETENTION OF SPATIAL MEMORY DEFICITS INDUCED BY POST-TRAUMATIC STRESS DISORDER IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MEHRABADI S.; MAKVAND HOSSEINI SH.; MILADI GORJI H.; NIKFARJAM HAFT ASIA M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Gorgan University of Medical Sciences Year:2012 | Volume:14 | Issue:3 (43) Page(s): 19-25

Download Full-Text

Persian Verion

View:

788

Download:

Cites:

Information Journal Paper

Title

PROTECTIVE EFFECTS OF DESMOPRESSIN ACETATE ON RETENTION OF SPATIAL MEMORY DEFICITS INDUCED BY POST-TRAUMATIC STRESS DISORDER IN RATS

Author(s)

MEHRABADI S. | MAKVAND HOSSEINI SH. | MILADI GORJI H. | NIKFARJAM HAFT ASIA M. | Issue Writer Certificate

Keywords

POST TRAUMATIC STRESS DISORDERQ2

MORRIS WATER MAZEQ2

LEARNINGQ2

SPATIAL MEMORYQ2

DESMOPRESSIN ACETATEQ2

Abstract

Background and Objective: Post-traumatic stress disorder (PTSD) impairs spatial LEARNING and memory. DESMOPRESSIN ACETATE ameliorates the cognitive deficits induced by electroconvulsive shock. This study was designed to evaluate the protective effects of DESMOPRESSIN ACETATE on retention of SPATIAL MEMORY deficits induced by post-traumatic stress disorder in rats.Materials and Methods: In this experimental study twenty one male Wistar rats were used. Animals were trained for 5 consecutive days in MORRIS WATER MAZE and then were randomly assigned in three groups (Vehicle + Sham, Saline + PTSD and DESMOPRESSIN ACETATE + PTSD) and tested in a probe 60 sec in 24h after the last acquisition trial. The groups of PTSD+Desmopressin acetate rats and vehicle+sham, saline+PTSD were injected DESMOPRESSIN ACETATE (10 micro gr/kg body weight) and saline (IP), respectively. Injections performed ten minute prior to PTSD and SPATIAL MEMORY was tested ten minutes later. Data were analyzed using SPSS-16, One-Way ANOVA and Tukey tests.Results: The platform location latency of the DESMOPRESSIN ACETATE+PTSD group was significantly shorter (4.24 sec) than the control group (P<0.05) and also, had significantly smaller average proximity values (33.87 cm) compared to the saline+PTSD group (P<0.05). DESMOPRESSIN ACETATE + PTSD spent significantly more time (21.65%) in the target zone (P<0.05).Conclusion: This study indicated that DESMOPRESSIN ACETATE blocks the ability of PTSD to impair SPATIAL MEMORY retention.

Cites

No record.

References

No record.

Cite

APA: Copy

MEHRABADI, S., MAKVAND HOSSEINI, SH., MILADI GORJI, H., & NIKFARJAM HAFT ASIA, M.. (2012). PROTECTIVE EFFECTS OF DESMOPRESSIN ACETATE ON RETENTION OF SPATIAL MEMORY DEFICITS INDUCED BY POST-TRAUMATIC STRESS DISORDER IN RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 14(3 (43)), 19-25. SID. https://sid.ir/paper/79168/en

Vancouver: Copy

MEHRABADI S., MAKVAND HOSSEINI SH., MILADI GORJI H., NIKFARJAM HAFT ASIA M.. PROTECTIVE EFFECTS OF DESMOPRESSIN ACETATE ON RETENTION OF SPATIAL MEMORY DEFICITS INDUCED BY POST-TRAUMATIC STRESS DISORDER IN RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;14(3 (43)):19-25. Available from: https://sid.ir/paper/79168/en

IEEE: Copy

S. MEHRABADI, SH. MAKVAND HOSSEINI, H. MILADI GORJI, and M. NIKFARJAM HAFT ASIA, “PROTECTIVE EFFECTS OF DESMOPRESSIN ACETATE ON RETENTION OF SPATIAL MEMORY DEFICITS INDUCED BY POST-TRAUMATIC STRESS DISORDER IN RATS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 3 (43), pp. 19–25, 2012, [Online]. Available: https://sid.ir/paper/79168/en

Related Journal Papers