FREQUNCEY OF PDCD1.3 GENE POLYMORPHISMS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS

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KHANJARI YOUSEF; SHAHRIARI ALI REZA; OLADNABI MORTEZA; ABDOLAHI NAFISEH

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:20 | Issue:1 (65) Page(s): 90-95

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Title

FREQUNCEY OF PDCD1.3 GENE POLYMORPHISMS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS

Author(s)

KHANJARI YOUSEF | SHAHRIARI ALI REZA | OLADNABI MORTEZA | ABDOLAHI NAFISEH | Issue Writer Certificate

Keywords

SYSTEMIC LUPUS ERYTHEMATOSUSQ2

PDCD1.3Q2

SEQUENCING METHODSQ1

SINGLE NUCLEOTIDE POLYMORPHISMSQ1

POLYMERASE CHAIN REACTIONQ1

Abstract

Background and Objective: SINGLE NUCLEOTIDE POLYMORPHISMS in programmed cell death which expressed at high level in T cells, plays an important role in the development and cause autoimmune disorders. This study was done to evaluate the frequncy of rs11568821 polymorphism in patients with SYSTEMIC LUPUS ERYTHEMATOSUS (SLE).Methods: This case-control study was done on 76 patients with SLE and 56 healthy controls. After DNA extraction, frequncy of polymorphisms PDCD1.3 by POLYMERASE CHAIN REACTION and SEQUENCING METHODS in subjects were determined.Results: There was a significant diference between frequency of allele and genotype at rs11568821 Polymorphism in region of intron 4 of PDCD1.3 gene in case and control groups (P<0.05). A allele and AG genotype was significantly higher in patients than healthy controls (9.5% vs 0.09%, P<0.05). There was no significant association between clinical and laboratory findings with genotype frequencies.Conclusion: rs11568821 single nucleotide polymorphism in intron 4 gene region PDCD1 can be used as a genetic factor to be involved the SLE susceptibility.

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APA: Copy

KHANJARI, YOUSEF, SHAHRIARI, ALI REZA, OLADNABI, MORTEZA, & ABDOLAHI, NAFISEH. (2018). FREQUNCEY OF PDCD1.3 GENE POLYMORPHISMS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 20(1 (65) ), 90-95. SID. https://sid.ir/paper/79315/en

Vancouver: Copy

KHANJARI YOUSEF, SHAHRIARI ALI REZA, OLADNABI MORTEZA, ABDOLAHI NAFISEH. FREQUNCEY OF PDCD1.3 GENE POLYMORPHISMS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;20(1 (65) ):90-95. Available from: https://sid.ir/paper/79315/en

IEEE: Copy

YOUSEF KHANJARI, ALI REZA SHAHRIARI, MORTEZA OLADNABI, and NAFISEH ABDOLAHI, “FREQUNCEY OF PDCD1.3 GENE POLYMORPHISMS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 1 (65) , pp. 90–95, 2018, [Online]. Available: https://sid.ir/paper/79315/en

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