MOLECULAR EVALUATION OF HEMOGLOBIN D MUTATIONS IN MAZANDARAN PROVINCE, IRAN

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MAHDAVI M.R.; ROSHAN P.; YOUSEFIAN N.; HOJJATI M.T.; HASHEMI SOTEH M.B.

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Journal: Journal of Gorgan University of Medical Sciences Year:2013 | Volume:15 | Issue:2 (46) Page(s): 65-69

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Title

MOLECULAR EVALUATION OF HEMOGLOBIN D MUTATIONS IN MAZANDARAN PROVINCE, IRAN

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Keywords

HEMOGLOBIN D PUNJABQ2

PCR-RFLPQ2

HEMOGLOBINOPATHYQ2

GENETIC MUTATIONQ2

Abstract

Background and Objective: Hemoglobinopathies are among the most prevalent genetic disorders worldwide, and occur as a result of mutations in the gene involved in synthesizing hemoglobin chains. By now more than 1000 defects in hemoglobin chains are discovered. Hemoglobin D (Hb D) is one of these disorders, identified by a single nucleotide mutation on codon 121 of beta globin chain. This study was carried out to evaluate Hb D mutations through molecular methods in Mazandaran province of Iran.Materials and Methods: This descriptive laboratory study was done on 70 patients with an electrophoresis band in hemoglobin-S zone in Mazandaran province of Iran during 2010-11. Capillary zone electrophoresis was done to find out Hb D in 51 patients. Subsequently, PCR-RFLP was performed to evaluate the samples at molecular level.Results: Molecular investigation revealed all cases are carriers of hemoglobin D-Punjab. Two patients were shown to be homozygote carriers of the abnormal gene.Conclusion: This study showed all Hb D affected patients were carriers of Hb D Punjab.

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APA: Copy

MAHDAVI, M.R., ROSHAN, P., YOUSEFIAN, N., HOJJATI, M.T., & HASHEMI SOTEH, M.B.. (2013). MOLECULAR EVALUATION OF HEMOGLOBIN D MUTATIONS IN MAZANDARAN PROVINCE, IRAN. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 15(2 (46)), 65-69. SID. https://sid.ir/paper/79342/en

Vancouver: Copy

MAHDAVI M.R., ROSHAN P., YOUSEFIAN N., HOJJATI M.T., HASHEMI SOTEH M.B.. MOLECULAR EVALUATION OF HEMOGLOBIN D MUTATIONS IN MAZANDARAN PROVINCE, IRAN. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;15(2 (46)):65-69. Available from: https://sid.ir/paper/79342/en

IEEE: Copy

M.R. MAHDAVI, P. ROSHAN, N. YOUSEFIAN, M.T. HOJJATI, and M.B. HASHEMI SOTEH, “MOLECULAR EVALUATION OF HEMOGLOBIN D MUTATIONS IN MAZANDARAN PROVINCE, IRAN,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 2 (46), pp. 65–69, 2013, [Online]. Available: https://sid.ir/paper/79342/en

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