GENOTOXIC AND CYTOTOXIC EFFECT OF MIRTAZAPINE IN HUMAN PERIPHERAL BLOOD LYMPHOCYTE: IN VITRO STUDY

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NORIZADEH TAZEHKAND M.; TOPAKTAS M.; HAJIPOUR O.

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Paper Information

Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2015 | Volume:17 | Issue:2 (54) Page(s): 98-103

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Title

GENOTOXIC AND CYTOTOXIC EFFECT OF MIRTAZAPINE IN HUMAN PERIPHERAL BLOOD LYMPHOCYTE: IN VITRO STUDY

Author(s)

NORIZADEH TAZEHKAND M. | TOPAKTAS M. | HAJIPOUR O. | Issue Writer Certificate

Keywords

MIRTAZAPINEQ2

CYTOTOXICITYQ2

GENOTOXICITYQ3

CHROMOSOME ABERRATIONQ2

MITOTIC INDEXQ2

LYMPHOCYTEQ3

Abstract

Background and Objective: MIRTAZAPINE is a norepinephrine and serotonergic antidepressant that is used in the theraphy of major depressive disorders. This study was carried out to determine the genotoxic and cytotoxic effect of MIRTAZAPINE using CHROMOSOME ABERRATION and MITOTIC INDEX tests in human peripheral blood LYMPHOCYTEs.Methods: In this descriptive -analytic study genotoxic and cytotoxic effect of MIRTAZAPINE at 24 and 48 hours treatment periods on four concentration (10, 25, 40, and 55mg/ml) was performed on peripheral blood LYMPHOCYTE of four subjects.Results: MIRTAZAPINE significantly reduced the MITOTIC INDEX in the all concentrations but it non-significantly increased the CHROMOSOME ABERRATION at 24-hours and 48-hours treatment periods.Conclusion: MIRTAZAPINE has cytotoxic effect but it has no genotoxic effect on human LYMPHOCYTE.

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APA: Copy

NORIZADEH TAZEHKAND, M., TOPAKTAS, M., & HAJIPOUR, O.. (2015). GENOTOXIC AND CYTOTOXIC EFFECT OF MIRTAZAPINE IN HUMAN PERIPHERAL BLOOD LYMPHOCYTE: IN VITRO STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 17(2 (54)), 98-103. SID. https://sid.ir/paper/79440/en

Vancouver: Copy

NORIZADEH TAZEHKAND M., TOPAKTAS M., HAJIPOUR O.. GENOTOXIC AND CYTOTOXIC EFFECT OF MIRTAZAPINE IN HUMAN PERIPHERAL BLOOD LYMPHOCYTE: IN VITRO STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;17(2 (54)):98-103. Available from: https://sid.ir/paper/79440/en

IEEE: Copy

M. NORIZADEH TAZEHKAND, M. TOPAKTAS, and O. HAJIPOUR, “GENOTOXIC AND CYTOTOXIC EFFECT OF MIRTAZAPINE IN HUMAN PERIPHERAL BLOOD LYMPHOCYTE: IN VITRO STUDY,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 2 (54), pp. 98–103, 2015, [Online]. Available: https://sid.ir/paper/79440/en

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