EFFECT OF AEROBIC EXERCISE AND ALPHA LIPOIC ACID SUPPLEMENT ON INSULIN RESISTANCE IN FEMALES WITH TYPE 2 DIABETES

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DARYANOOSH F.; SHKIBAIE M.; ZAMANIE A.; MOHAMMADI M.

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2015 | Volume:17 | Issue:3 (55) Page(s): 75-80

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Information Journal Paper

Title

EFFECT OF AEROBIC EXERCISE AND ALPHA LIPOIC ACID SUPPLEMENT ON INSULIN RESISTANCE IN FEMALES WITH TYPE 2 DIABETES

Author(s)

DARYANOOSH F. | SHKIBAIE M. | ZAMANIE A. | MOHAMMADI M. | Issue Writer Certificate

Keywords

TYPE 2 DIABETICQ2

ALPHA LIPOIC ACIDQ2

EXERCISEQ2

INSULINQ2

Abstract

Background and Objective: ALPHA LIPOIC ACID (ALA) is a powerful biological antioxidant which is involved in metabolism and energy production as a co-factor in mitochondrial dehydrogenase enzyme complex. This study was done to evaluate the effect of aerobic EXERCISE and ALPHA LIPOIC ACID supplement on INSULIN resistance in females with type 2 diabetes.Methods: In this quasi-experimental study, 44 females with type 2 diabetes divided into four groups including: control, supplementation, training and supplementation + training groups. Patients of supplementation and complex (supplementation + training) groups took three 100mg ALA capsules per day for eight weeks. The training program consisted of 8 weeks and three sessions per week. In each session, the subjects warmed up for 10-15 minutes, ran on a treadmill with the intensity of 40-50% of maximum heart rate for 30 minutes and then cooled down for 5-10 minutes. Blood samples were taken after 12-14 hours fasting in two stages - the beginning and the end of the eighth week.Results: Eight weeks of taking ALA supplements significantly reduced patients’ INSULIN resistance (P<0.05). Eight weeks of running on a treadmill with an intensity of 40-50% of maximum heart rate non-significantly reduced INSULIN resistance in the training group compared to the controls. In the supplementation + training group a significant reduction of INSULIN resistance was observed (P<0.05).Conclusion: ALPHA LIPOIC ACID supplementation reduces INSULIN and INSULIN resistance. While, reduction in fasting blood glucose level causes reduction in INSULIN resistance in the combination of supplementation and training.

Cites

تاثیر فعالیت های ورزشی استقامتی بر گلوکز خون، انسولین و مقاومت به انسولین در بیماران مبتلا به دیابت نوع دو: یک مرور نظام مند و فراتحلیل بر مطالعات صورت گرفته در داخل ایران

References

RELATIONSHIP BETWEEN CARDIOVASCULAR RISK FACTORS AND BLOOD ADIPONECTIN IN DIABETIC MALES

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APA: Copy

DARYANOOSH, F., SHKIBAIE, M., ZAMANIE, A., & MOHAMMADI, M.. (2015). EFFECT OF AEROBIC EXERCISE AND ALPHA LIPOIC ACID SUPPLEMENT ON INSULIN RESISTANCE IN FEMALES WITH TYPE 2 DIABETES. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 17(3 (55)), 75-80. SID. https://sid.ir/paper/79467/en

Vancouver: Copy

DARYANOOSH F., SHKIBAIE M., ZAMANIE A., MOHAMMADI M.. EFFECT OF AEROBIC EXERCISE AND ALPHA LIPOIC ACID SUPPLEMENT ON INSULIN RESISTANCE IN FEMALES WITH TYPE 2 DIABETES. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;17(3 (55)):75-80. Available from: https://sid.ir/paper/79467/en

IEEE: Copy

F. DARYANOOSH, M. SHKIBAIE, A. ZAMANIE, and M. MOHAMMADI, “EFFECT OF AEROBIC EXERCISE AND ALPHA LIPOIC ACID SUPPLEMENT ON INSULIN RESISTANCE IN FEMALES WITH TYPE 2 DIABETES,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 3 (55), pp. 75–80, 2015, [Online]. Available: https://sid.ir/paper/79467/en

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