EFFICACY OF DEFROXAMINE- DEFERIPRONE ON CARDIAC FUNCTION OF PATIENTS WITH MAJOR THALASSEMIA

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MIRBEHBAHANI N.B.; NIKYAR B.; BEHNAMPOUR N.; RASHIDBAGHAN A.; KIANI M.; NIKYAR A.

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2015 | Volume:17 | Issue:3 (55) Page(s): 96-100

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Title

EFFICACY OF DEFROXAMINE- DEFERIPRONE ON CARDIAC FUNCTION OF PATIENTS WITH MAJOR THALASSEMIA

Author(s)

Keywords

THALASSEMIA MAJORQ3

DEFERIPRONEQ3

DEFEROXAMINEQ3

FERRITINQ3

LVEFQ2

Abstract

Background and Objective: Deferoxamin is the current “gold standard” chelator in comparison with new chelators. Combined therapy of DEFERIPRONE and deferoxamin reduces the cardiac iron overload in patients with major talassemia. This study was done to evaluate the effect of defriprone-deferoxamine on heart function in patients with major thalassemia.Methods: In this historical cohort study, 8 patients with major beta thalassemia treated by subcutaneous DEFEROXAMINE were randomly selected and LVEF (the rate of blood that exited from heart in each beat) and serum FERRITIN were measeared. The patients were treated by DEFERIPRONE (50-100 mg/kg/day) compained with dferoxamine (30-50 mg/kg as 3 times in a week). In the end of each year, LVEF and serum FERRITIN of patients were measured.Results: The FERRITIN level changed from 3243.12 in the first year to 2672.75 mg/kg at the end of third year. The mean of LVEF changed from 71.12% to 64.62 %. The correlation of serum FERRITIN and LVEF only at the end of third year was significant (P<0.05).Conclusion: Combined therapy of DEFERIPRONE-deferoxamine during 3 years reduces FERRITIN and LVEF in patients with major thalassemia.

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References

COMPARISON BETWEEN DEFEROXAMINE AND COMBINED THERAPY WITH DEFEROXAMINE AND DEFERIPRONE IN IRON OVERLOADED THALASSEMIA PATIENTS

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APA: Copy

MIRBEHBAHANI, N.B., NIKYAR, B., BEHNAMPOUR, N., RASHIDBAGHAN, A., KIANI, M., & NIKYAR, A.. (2015). EFFICACY OF DEFROXAMINE- DEFERIPRONE ON CARDIAC FUNCTION OF PATIENTS WITH MAJOR THALASSEMIA. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 17(3 (55)), 96-100. SID. https://sid.ir/paper/79469/en

Vancouver: Copy

MIRBEHBAHANI N.B., NIKYAR B., BEHNAMPOUR N., RASHIDBAGHAN A., KIANI M., NIKYAR A.. EFFICACY OF DEFROXAMINE- DEFERIPRONE ON CARDIAC FUNCTION OF PATIENTS WITH MAJOR THALASSEMIA. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;17(3 (55)):96-100. Available from: https://sid.ir/paper/79469/en

IEEE: Copy

N.B. MIRBEHBAHANI, B. NIKYAR, N. BEHNAMPOUR, A. RASHIDBAGHAN, M. KIANI, and A. NIKYAR, “EFFICACY OF DEFROXAMINE- DEFERIPRONE ON CARDIAC FUNCTION OF PATIENTS WITH MAJOR THALASSEMIA,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 3 (55), pp. 96–100, 2015, [Online]. Available: https://sid.ir/paper/79469/en

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