EFFECT OF HAEMODIALYSIS ON PLASMA LIPID PEROXIDATION AND ERYTHROCYTE ANTIOXIDANT ENZYME IN GORGAN

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MOUJERLOU M.; MANSOURIAN AR.; RABIEI M.R.; MARJANI A.A.J.

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Journal: Journal of Gorgan University of Medical Sciences Year:2004 | Volume:6 | Issue:13 Page(s): 83-89

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Title

EFFECT OF HAEMODIALYSIS ON PLASMA LIPID PEROXIDATION AND ERYTHROCYTE ANTIOXIDANT ENZYME IN GORGAN

Author(s)

MOUJERLOU M. | MANSOURIAN AR. | RABIEI M.R. | MARJANI A.A.J. | Issue Writer Certificate

Keywords

HAEMODIALYSIS- LIPID PEROXIDATION- ANTIOXIDANT ENZYMEQ3

Abstract

New Page 1 Background&Objective: Free radicals are formed in all living organisms during normal cell metabolism. Patients with chronic renal failure, which regularly dialysed are the candidates for, free radical damage. The aim of this study with the discriminative infonnatiol1 was to evaluate the effect of haemodialysis on lipid peroxidation (the level of lipid peroxidation expressed as malondialdehyde) and erythrocyte antioxidant enzyme (glutatl}ioneperoxidase) before and after the dialysis and compared with control group, to ,find out the effect of haemodialysis on the level of lipid peroxidation of plasma and the activity of erythrocyte antioxidant enzyme. Materials&Methods: This investigation was an analytical type of study and sampling procedure was according to purposive method: 22 patients with chronic renal failure( CRF) disease who were haemodialysed at 5th Azar hospital of Gorgan dialysis center and 22 age and sex matched healthy control were recruited for this study.The data was analysed by SPSS software using T -test. /" Results: Plasma malondialdehyde showed significant. difference between the predialysis (and control group. It was increased in the postdialysis group (2.32 ±0.38 nmol/m!) when compared with predialysis (1.27± 0.23 nmol/ml) and control group (0.98 ± 0.17 nmol/ml). Erythrocyte antioxidant enzyme was decreased in postdialysis group (22.26 ± 4.76 unit/gram hemoglobin) when compared with predialysis (29.66± 5.95 unit/gram hemoglobin) and control group (37.52± 6.26 unit/gram hemoglobin). There was also significant difference between control and predialysis group. Erythrocyte antioxidant enzyme was lower than control group in dialysis group. Conclusion: The observation of meaningful differeneces in reduction of erythrocyte antioxidant enzyme and increasing level of plasma lipid peroxidation in the haemodialysed pateints after the process of dialysis maybe related with the pateint, uremia, dialysis membrane (the loosing antioxidant enzyme through this membrane), and the dialysis process (may increase lipid peroxidation during the dialysis process). These states of affairs may play an inpotant role in progress of cardiovascular abnonnality in haemodialysed pateints. Due to this conditions a review of haen;lOdialysis membrane, the techniques used in the dialysis, the consumption of various oral antioxidant, the elimination of active oxygens from the dialysis srrounding are among the measures which can prevent sudden cardiovascular abnormality in the haemodialysis pateints and ultimately these important factors up- grade the pateints quality of life.

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APA: Copy

MOUJERLOU, M., MANSOURIAN, AR., RABIEI, M.R., & MARJANI, A.A.J.. (2004). EFFECT OF HAEMODIALYSIS ON PLASMA LIPID PEROXIDATION AND ERYTHROCYTE ANTIOXIDANT ENZYME IN GORGAN. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 6(13), 83-89. SID. https://sid.ir/paper/79515/en

Vancouver: Copy

MOUJERLOU M., MANSOURIAN AR., RABIEI M.R., MARJANI A.A.J.. EFFECT OF HAEMODIALYSIS ON PLASMA LIPID PEROXIDATION AND ERYTHROCYTE ANTIOXIDANT ENZYME IN GORGAN. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2004;6(13):83-89. Available from: https://sid.ir/paper/79515/en

IEEE: Copy

M. MOUJERLOU, AR. MANSOURIAN, M.R. RABIEI, and A.A.J. MARJANI, “EFFECT OF HAEMODIALYSIS ON PLASMA LIPID PEROXIDATION AND ERYTHROCYTE ANTIOXIDANT ENZYME IN GORGAN,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 6, no. 13, pp. 83–89, 2004, [Online]. Available: https://sid.ir/paper/79515/en

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