THE EFFECT OF ZNO NPS OF 20 NM ON CHANGES OF ENZYME AND LIVER TISSUES OF PREGNANT NMRI MICE

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SEYED ALIPOUR BAGER; OSHRIEH MASOOMEH; KHANBABAEE RAMEZAN

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Journal: Yafteh Year:2014 | Volume:16 | Issue:3 (61) Page(s): 85-92

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Title

THE EFFECT OF ZNO NPS OF 20 NM ON CHANGES OF ENZYME AND LIVER TISSUES OF PREGNANT NMRI MICE

Author(s)

SEYED ALIPOUR BAGER | OSHRIEH MASOOMEH | KHANBABAEE RAMEZAN | Issue Writer Certificate

Keywords

TOXICITY PROPERTIESQ2

ZNO NPSQ1

LIVER ENZYMESQ2

HEPATOCYTEQ2

Abstract

Background: Nowadays, nanotechnology has been developing rapidly and may have considerable effects on industry, society and the environment. In this research the TOXICITY PROPERTIES of zinc oxide nanoparticles with a size of 20 nm on enzyme and liver tissue of NMRI mice were studied.Materials and Methods: This experimental study was performed in standard conditions on 25 NMRI mice with an average weight of 30±3 g so that they received different doses of zinc oxide nanoparticles, an a days, for 15 days intraperitoneally. Then, blood samples were taken on day 17 of NMRI mice. The collected tissues were washed with saline and fixed in Boin’s fluied buffer and stained with hematoxylin and eosin for histopathology evaluation. After data collection, statistical analysis was done using SAS software.Results: The results showed that activity of ALT enzyme at concentrations 50, 100, 150 and 200 mg/kg ZNO NPS at a significant level (p<0.05) increased in comparison with the control group. Histopathological investigation showed that zinc oxide nanoparticles caused severe damage in liver. Damaged liver cells develop leaky membranes and escape of intracellular enzymes into the bloodstream.Conclusion: Our findings showed that using different concentration of zinc oxide nanoparticles could be caused undesirable effects on liver with damage to HEPATOCYTE and level elevation of LIVER ENZYMES.

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APA: Copy

SEYED ALIPOUR, BAGER, OSHRIEH, MASOOMEH, & KHANBABAEE, RAMEZAN. (2014). THE EFFECT OF ZNO NPS OF 20 NM ON CHANGES OF ENZYME AND LIVER TISSUES OF PREGNANT NMRI MICE. YAFTEH, 16(3 (61)), 85-92. SID. https://sid.ir/paper/79978/en

Vancouver: Copy

SEYED ALIPOUR BAGER, OSHRIEH MASOOMEH, KHANBABAEE RAMEZAN. THE EFFECT OF ZNO NPS OF 20 NM ON CHANGES OF ENZYME AND LIVER TISSUES OF PREGNANT NMRI MICE. YAFTEH[Internet]. 2014;16(3 (61)):85-92. Available from: https://sid.ir/paper/79978/en

IEEE: Copy

BAGER SEYED ALIPOUR, MASOOMEH OSHRIEH, and RAMEZAN KHANBABAEE, “THE EFFECT OF ZNO NPS OF 20 NM ON CHANGES OF ENZYME AND LIVER TISSUES OF PREGNANT NMRI MICE,” YAFTEH, vol. 16, no. 3 (61), pp. 85–92, 2014, [Online]. Available: https://sid.ir/paper/79978/en

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