NEUROPROTECTIVE AND BEHAVIORAL EFFICACY OF INTRAVENOUS TRANSPLANTED ADIPOSE STEM CELLS IN EXPERIMENTAL PARKINSONIAN RAT MODELS

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NAKHAEIFARD MALIHE; HAJI GHASEM KASHANI MARYAM; GOUDARZI IRAN; KOSHA ABOTALEB

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Journal: Yafteh Year:2016 | Volume:17 | Issue:4 (66) Page(s): 84-91

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Title

NEUROPROTECTIVE AND BEHAVIORAL EFFICACY OF INTRAVENOUS TRANSPLANTED ADIPOSE STEM CELLS IN EXPERIMENTAL PARKINSONIAN RAT MODELS

Author(s)

NAKHAEIFARD MALIHE | HAJI GHASEM KASHANI MARYAM | GOUDARZI IRAN | KOSHA ABOTALEB | Issue Writer Certificate

Keywords

ADIPOSE-DERIVED STEMCELLSQ1

PARKINSON’S DISEASEQ2

MOTOR DISABILITYQ2

ROTARODQ2

APOMORPHINE INDUCED ROTATIONQ2

Abstract

Background: Parkinson's disease is a deficiency of dopamine in the striatum, characterized by bradykinesis, rigidity and resting tremor. Adipose tissue-Derived Stem Cells (ADSCs) have many advantages for cell therapy because of the easy availability and pluripotency without ethical problems. In this research, the effects of ADSCs transplantation on motor impairment of rat Parkinsonian models were evaluated.Materials and Methods: Parkinson model was constructed by the unilateral lesion of striatum of male Wistar rats using 20µg of 6-hydroxydopamine (6-OHDA) as lesion group. Cell and α-MEM (α-minimal essential medium) groups were lesioned animals that received intravenous injection of 3×106 cells suspended in medium and medium repectively. All rats were evaluated behaviorally with ROTAROD and apomorphine-induced rotation tests, at 4 and 8 weeks after cell transplantation.Results: Lesion and α-MEM groups showed increased contralateral turns while cell group significantly ameliorated both in ROTAROD and apomorphine-induced rotation tests. There was a significant difference of contralateral turns between cell and lesioned groups at 8 weeks after transplantation. Lesioned rats showed significant decrease of staying on the rod as compared to control, but in cell group there was a significant increase in comparision with the lesioned animals.Conclusion: ADSCs injected intravenously promote functional recovery in Parkinsonian rats.

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APA: Copy

NAKHAEIFARD, MALIHE, HAJI GHASEM KASHANI, MARYAM, GOUDARZI, IRAN, & KOSHA, ABOTALEB. (2016). NEUROPROTECTIVE AND BEHAVIORAL EFFICACY OF INTRAVENOUS TRANSPLANTED ADIPOSE STEM CELLS IN EXPERIMENTAL PARKINSONIAN RAT MODELS. YAFTEH, 17(4 (66)), 84-91. SID. https://sid.ir/paper/80203/en

Vancouver: Copy

NAKHAEIFARD MALIHE, HAJI GHASEM KASHANI MARYAM, GOUDARZI IRAN, KOSHA ABOTALEB. NEUROPROTECTIVE AND BEHAVIORAL EFFICACY OF INTRAVENOUS TRANSPLANTED ADIPOSE STEM CELLS IN EXPERIMENTAL PARKINSONIAN RAT MODELS. YAFTEH[Internet]. 2016;17(4 (66)):84-91. Available from: https://sid.ir/paper/80203/en

IEEE: Copy

MALIHE NAKHAEIFARD, MARYAM HAJI GHASEM KASHANI, IRAN GOUDARZI, and ABOTALEB KOSHA, “NEUROPROTECTIVE AND BEHAVIORAL EFFICACY OF INTRAVENOUS TRANSPLANTED ADIPOSE STEM CELLS IN EXPERIMENTAL PARKINSONIAN RAT MODELS,” YAFTEH, vol. 17, no. 4 (66), pp. 84–91, 2016, [Online]. Available: https://sid.ir/paper/80203/en

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