EFFECT OF CAFFEINE ON SPONTANEOUS ACTIVITY OF PARAGIGANTOCELLULARIS NEURONS AND EHAVIORAL PARAMETERS OF WITHDRAWAL SYNDROM IN MORPHINE DEPENDENT RATS

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KHALILI M.; SEMNANIAN S.; FATH ELAHI Y.; MAHDAVI M.

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Journal: Pathobiology Research Year:2001 | Volume:3 | Issue:2 Page(s): 89-94

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Title

EFFECT OF CAFFEINE ON SPONTANEOUS ACTIVITY OF PARAGIGANTOCELLULARIS NEURONS AND EHAVIORAL PARAMETERS OF WITHDRAWAL SYNDROM IN MORPHINE DEPENDENT RATS

Author(s)

KHALILI M. | SEMNANIAN S. | FATH ELAHI Y. | MAHDAVI M. | Issue Writer Certificate

Keywords

MORPHINE TOLERANCE AND DEPENDENCEQ4

NUCLEUS PARAGIGANTOCELLULARISQ4

SINGLE UNIT RECORDINGQ4

CAFFEINEQ4

WITHDRAWAL SIGNSQ2

Abstract

Using SINGLE UNIT RECORDING in the nucleus paragigantocellaris (PGi) neurons, located in the rostral ventrolateral medulla and measuring the precipitated withdrawal syndrome, we investigated whether chronic morphine administration would produce the adaptive changes in adenosine system.Caffeine (50 mg/kg; i.p.) induced WITHDRAWAL SIGNS (head shakes, teeth chattering, ejaculation, chewing, and irritability) in morphine dependent rats 10-18 min after the injection. But only the teeth chattering and diarrhea were expressed following a direct PGi injection of CAFFEINE (200µM; 0.5µ1). There was also a significant enhancement of spontaneous activity of PGi neurons 8-15 min after CAFFEINE administration (50 mg/kg; i.p.) in both control and morphine-dependent rats.However the effect of CAFFEINE in morphine-dependent rats was higher than that of control ones.These data suggest that there is an increase in sensitivity to chemicals, which interact with adenosine receptors in morphine dependent rats, and the adaptive changes in PGi adenosine system due to chronic morphine play a role in the expression of physical dependence on opioids.

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APA: Copy

KHALILI, M., SEMNANIAN, S., FATH ELAHI, Y., & MAHDAVI, M.. (2001). EFFECT OF CAFFEINE ON SPONTANEOUS ACTIVITY OF PARAGIGANTOCELLULARIS NEURONS AND EHAVIORAL PARAMETERS OF WITHDRAWAL SYNDROM IN MORPHINE DEPENDENT RATS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 3(2), 89-94. SID. https://sid.ir/paper/80996/en

Vancouver: Copy

KHALILI M., SEMNANIAN S., FATH ELAHI Y., MAHDAVI M.. EFFECT OF CAFFEINE ON SPONTANEOUS ACTIVITY OF PARAGIGANTOCELLULARIS NEURONS AND EHAVIORAL PARAMETERS OF WITHDRAWAL SYNDROM IN MORPHINE DEPENDENT RATS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2001;3(2):89-94. Available from: https://sid.ir/paper/80996/en

IEEE: Copy

M. KHALILI, S. SEMNANIAN, Y. FATH ELAHI, and M. MAHDAVI, “EFFECT OF CAFFEINE ON SPONTANEOUS ACTIVITY OF PARAGIGANTOCELLULARIS NEURONS AND EHAVIORAL PARAMETERS OF WITHDRAWAL SYNDROM IN MORPHINE DEPENDENT RATS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 3, no. 2, pp. 89–94, 2001, [Online]. Available: https://sid.ir/paper/80996/en

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