THE EFFECTS OF ARTEMISININ AND AQUEOUS AND ALCOHOLIC EXTRACTS OF ARTEMISIA ANNUA ON ACANTHAMOEBA GENOTYPE T4 IN VITRO

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NAYERI CHEGENI TOORAN; GHAFFARIFAR FATEMEH; KHOSHZABAN FARIBA; DALIMI ASL ABDOLHOSEIN

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Journal: Pathobiology Research Year:2016 | Volume:19 | Issue:2 Page(s): 75-87

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Title

THE EFFECTS OF ARTEMISININ AND AQUEOUS AND ALCOHOLIC EXTRACTS OF ARTEMISIA ANNUA ON ACANTHAMOEBA GENOTYPE T4 IN VITRO

Author(s)

NAYERI CHEGENI TOORAN | GHAFFARIFAR FATEMEH | KHOSHZABAN FARIBA | DALIMI ASL ABDOLHOSEIN | Issue Writer Certificate

Keywords

TROPHOZOITEQ1

CYSTQ1

ACANTHAMOEBAQ1

ARTEMISIA ANNUAQ3

IN VITROQ2

Abstract

Objective: Free-living amoebae, including ACANTHAMOEBA constitute a large group of amoebae that live in fresh water, salty and bitter, moist soil, carious plants, and some on the stool. They are medically important agents. It is a medically important agent. The aim of the present study is to determine the effects of aqueous and alcoholic extracts of ARTEMISIA ANNUAon TROPHOZOITEs and CYSTs of ACANTHAMOEBA IN VITRO.Methods: In this experimental research, after genotyping the clinical isolate, we prepared the aqueous and alcoholic extracts of ARTEMISIA ANNUA. Various concentrations (1.25, 2.5, 5, and 10 mg/ml) of the aqueous and alcoholic extracts of this plant as well as artemisinin were tested at three different times (24, 48 and 72 h) on TROPHOZOITEs and CYSTs of ACANTHAMOEBAin vitro. We evaluated viability of the parasite by trypan blue, MTT, and flow cytometry analyses.Results: We observed the anti-acanthamoeba activity of different concentrations of the Artemisia extract. In the presence of 10 mg/ml alcoholic extract in medium culture after 72 h, we observed that 30.51% TROPHOZOITEs and 91.40% CYSTs of ACANTHAMOEBA were viable. However, in the presence of 10 mg/ml aqueous extract of ARTEMISIA ANNUA, only 58.25% TROPHOZOITEs and 81.53% CYSTs were alive in the in medium culture after 72 h.Conclusion: Aqueous and alcoholic extracts of ARTEMISIA ANNUA had dose- and time dependent anti-acanthamoeba activity.

Cites

Effect of Aqueous Extract of Peganum harmala on Acanthamoeba In Vitro

References

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APA: Copy

NAYERI CHEGENI, TOORAN, GHAFFARIFAR, FATEMEH, KHOSHZABAN, FARIBA, & DALIMI ASL, ABDOLHOSEIN. (2016). THE EFFECTS OF ARTEMISININ AND AQUEOUS AND ALCOHOLIC EXTRACTS OF ARTEMISIA ANNUA ON ACANTHAMOEBA GENOTYPE T4 IN VITRO. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 19(2), 75-87. SID. https://sid.ir/paper/81033/en

Vancouver: Copy

NAYERI CHEGENI TOORAN, GHAFFARIFAR FATEMEH, KHOSHZABAN FARIBA, DALIMI ASL ABDOLHOSEIN. THE EFFECTS OF ARTEMISININ AND AQUEOUS AND ALCOHOLIC EXTRACTS OF ARTEMISIA ANNUA ON ACANTHAMOEBA GENOTYPE T4 IN VITRO. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2016;19(2):75-87. Available from: https://sid.ir/paper/81033/en

IEEE: Copy

TOORAN NAYERI CHEGENI, FATEMEH GHAFFARIFAR, FARIBA KHOSHZABAN, and ABDOLHOSEIN DALIMI ASL, “THE EFFECTS OF ARTEMISININ AND AQUEOUS AND ALCOHOLIC EXTRACTS OF ARTEMISIA ANNUA ON ACANTHAMOEBA GENOTYPE T4 IN VITRO,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 19, no. 2, pp. 75–87, 2016, [Online]. Available: https://sid.ir/paper/81033/en

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