EVALUATION OF CHITOSAN/POLY (VINYL ALCOHOL) NANO-COMPOSITE BIOCOMPATIBILITY FOR NEURAL CELLS PROLIFERATION

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MOTAGHITALAB F.; MOTAGHITALAB VAHID; FAROKHI MAHDI; ESLAMIFAR A.; SHOKRGOZAR M.A.

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Journal: Pathobiology Research Year:2009 | Volume:12 | Issue:3 Page(s): 51-60

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Title

EVALUATION OF CHITOSAN/POLY (VINYL ALCOHOL) NANO-COMPOSITE BIOCOMPATIBILITY FOR NEURAL CELLS PROLIFERATION

Author(s)

Keywords

TISSUE ENGINEERINGQ2

NANOCOMPOSITEQ2

CHITOSANQ2

POLY (VINYL ALCOHOL)Q3

ELECTROSPINNINGQ2

Abstract

Objective: TISSUE ENGINEERING is an (interdisciplinary field that applies polymeric scaffolds to control tissue formation in three-dinemtion (3D). The scaffold provides the microenvironment (synthetic temporary extracellular matrix) for regenerative cells, supporting cell attachment, proliferation, differentiation, and neo tissue genesis due to their suitable chemical, physical and biological structures. In this study, CHITOSAN/poly (vinyl alcohol) (CS/PVA) was exploited as scaffold for nerve regeneration. Materials and Methods: ELECTROSPINNING was used to fabricate CS/PVA NANOCOMPOSITEs for U373 cells seeding and proliferation. ELECTROSPINNING is a versatile and simple method to fabricate nonwoven thin layer fibers from polymeric solutions. Consequently, the biocompatibility of CS/PVAnanocomposite was evaluated using biological assays and cell attachment study.Results: Results indicated that CS/PVA NANOCOMPOSITEs with 15/85 proportion shown an almost homogenous network of the electrospun fibers and confirmed that they can be knitted in meshes and improve U373 cells proliferation and cell attachment.Conclusion: The nano-sized CS/PVA scaffolds are nontoxic and biocompatible which can promote proliferation of U373 cells and their appropriate adhesion to NANOCOMPOSITE for improved peripheral nerve regeneration.

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APA: Copy

MOTAGHITALAB, F., MOTAGHITALAB, VAHID, FAROKHI, MAHDI, ESLAMIFAR, A., & SHOKRGOZAR, M.A.. (2009). EVALUATION OF CHITOSAN/POLY (VINYL ALCOHOL) NANO-COMPOSITE BIOCOMPATIBILITY FOR NEURAL CELLS PROLIFERATION. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 12(3), 51-60. SID. https://sid.ir/paper/81129/en

Vancouver: Copy

MOTAGHITALAB F., MOTAGHITALAB VAHID, FAROKHI MAHDI, ESLAMIFAR A., SHOKRGOZAR M.A.. EVALUATION OF CHITOSAN/POLY (VINYL ALCOHOL) NANO-COMPOSITE BIOCOMPATIBILITY FOR NEURAL CELLS PROLIFERATION. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2009;12(3):51-60. Available from: https://sid.ir/paper/81129/en

IEEE: Copy

F. MOTAGHITALAB, VAHID MOTAGHITALAB, MAHDI FAROKHI, A. ESLAMIFAR, and M.A. SHOKRGOZAR, “EVALUATION OF CHITOSAN/POLY (VINYL ALCOHOL) NANO-COMPOSITE BIOCOMPATIBILITY FOR NEURAL CELLS PROLIFERATION,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 12, no. 3, pp. 51–60, 2009, [Online]. Available: https://sid.ir/paper/81129/en

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