DIAGNOSTIC VALUE OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES IN PATIENTS WITH RHEUMATOID ARTHRITIS

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JOUKAR M.H.; MAHMOUDI MAHMOUD; HESARI S.; SOBHANI M.

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Journal: Pathobiology Research Year:2008 | Volume:10 | Issue:3-4 Page(s): 59-64

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Title

DIAGNOSTIC VALUE OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES IN PATIENTS WITH RHEUMATOID ARTHRITIS

Author(s)

JOUKAR M.H. | MAHMOUDI MAHMOUD | HESARI S. | SOBHANI M. | Issue Writer Certificate

Keywords

ANTI-CCPQ3

RHEUMATOID ARTHRITISQ3

RHEUMATOID FACTORQ3

Abstract

Objective: Anti-cyclic citrullinated peptide (ANTI-CCP) antibodies are highly specific markers for RHEUMATOID ARTHRITIS (RA) and useful for predicting RHEUMATOID ARTHRITIS (RA) development and progression. We assessed the diagnostic value of ANTI-CCP antibodies in our patients with RA. Materials and Methods: ANTI-CCP antibodies and RHEUMATOID FACTOR (RF) titers were determined in 247 serum samples: 128 from RA patients, 119 from control group (48 from healthy controls, 71 from patients with rheumatic disease other than RA or hematologic malignancies). Results: There were 128 (93 females, 35 males) patients with RHEUMATOID ARTHRITIS and 119 (78 females, 41 males) controls. The sensitivity of ANTI-CCP was 66.40% for diagnosis of RA with a specificity of 94.11%. The sensitivity of RF was 69.53% and its specificity was 81.51%. Conclusion: In our patients ANTI-CCP has a moderate sensitivity but high specificity for diagnosis of RA.

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APA: Copy

JOUKAR, M.H., MAHMOUDI, MAHMOUD, HESARI, S., & SOBHANI, M.. (2008). DIAGNOSTIC VALUE OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES IN PATIENTS WITH RHEUMATOID ARTHRITIS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 10(3-4), 59-64. SID. https://sid.ir/paper/81149/en

Vancouver: Copy

JOUKAR M.H., MAHMOUDI MAHMOUD, HESARI S., SOBHANI M.. DIAGNOSTIC VALUE OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES IN PATIENTS WITH RHEUMATOID ARTHRITIS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2008;10(3-4):59-64. Available from: https://sid.ir/paper/81149/en

IEEE: Copy

M.H. JOUKAR, MAHMOUD MAHMOUDI, S. HESARI, and M. SOBHANI, “DIAGNOSTIC VALUE OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES IN PATIENTS WITH RHEUMATOID ARTHRITIS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 10, no. 3-4, pp. 59–64, 2008, [Online]. Available: https://sid.ir/paper/81149/en

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