EFFECT OF ADENOSINE A1 RECEPTORS ACTIVITY OF NUCLEUS ACCUMBENS ON AMYGDALA KINDLED SEIZURES IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ROZATI S.A.; MIRNAJAFIZADEH S.J.; FATH ELAHI Y.; MOHAMMADZADEH M.; PALIZVAN M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pathobiology Research Year:2004 | Volume:7 | Issue:1 Page(s): 49-59

Download Full-Text

Persian Verion

View:

782

Download:

Cites:

Information Journal Paper

Title

EFFECT OF ADENOSINE A1 RECEPTORS ACTIVITY OF NUCLEUS ACCUMBENS ON AMYGDALA KINDLED SEIZURES IN RATS

Author(s)

Keywords

SEIZUREQ4

ADENOSINEQ4

AMYGDALAQ3

NUCLEUS ACCUMBENSQ3

KINDLINGQ3

Abstract

Purpose: The role of ADENOSINE AI receptors of the NUCLEUS ACCUMBENS on AMYGDALA kindled SEIZUREs was investigated.Materials and Methods: All animals were implanted with a triplolar (stimulating and recording) electrode in the AMYGDALA and tow guide cannula in the NUCLEUS ACCUMBENS. Animals were kindled by daily electrical stimulating of the AMYGDALA. In the full kindled animals, N6- cyclohexyladenosine (CHA; 1, 5 , 10 µM), an ADENOSINE A1 receptor agonist, was injected bilaterally into the NUCLEUS ACCUMBENS.Results: Obtained results showed that CHA at the concentration of 10µM reduces the AMYGDALA afterdischarge duration (A-ADD), at 5, 15, 60 and 120 min post drug injection. It also decreased the stage 5 duration (S5D), but reduced the accumbens afterdischarge duration (Acc-ADD), at 15 min post drug injection, and increased the latency of the stage 4 SEIZURE (S4L) at 5 and 15min post drug infusion. In addition, at the concentration of 5 µM, the S4L was increased and the S5D was decreased at 5 and 15 minpost drug injection. The bilateral injection of8- cyclopenthyl-l,3- dimethylxanthine (CPT), an ADENOSINE A1 receptor antagonist, at the concentration of 5 µM into the NUCLEUS ACCUMBENS did not alter the SEIZURE parameters. The intra- nucleus accubens infusion of CPT (5µM), 5 min before CHA (10µM) blocked the anticonvulsant effects of CHA.Conclusion: These results suggest that the NUCLEUS ACCUMBENS has a role in the SEIZURE propagation from the AMYGDALA and it's ADENOSINE AI receptors activity has anticonvulsant effects in AMYGDALA kindled rats.

Cites

ADENOSINE A1 RECEPTORS OF AMYGDALA HAS NOT ANTICONVULSANT EFFECTS ON PIRIFORM CORTEX KINDLED SEIZURES IN RATS

References

No record.

Cite

APA: Copy

ROZATI, S.A., MIRNAJAFIZADEH, S.J., FATH ELAHI, Y., MOHAMMADZADEH, M., & PALIZVAN, M.R.. (2004). EFFECT OF ADENOSINE A1 RECEPTORS ACTIVITY OF NUCLEUS ACCUMBENS ON AMYGDALA KINDLED SEIZURES IN RATS . PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 7(1), 49-59. SID. https://sid.ir/paper/81235/en

Vancouver: Copy

ROZATI S.A., MIRNAJAFIZADEH S.J., FATH ELAHI Y., MOHAMMADZADEH M., PALIZVAN M.R.. EFFECT OF ADENOSINE A1 RECEPTORS ACTIVITY OF NUCLEUS ACCUMBENS ON AMYGDALA KINDLED SEIZURES IN RATS . PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2004;7(1):49-59. Available from: https://sid.ir/paper/81235/en

IEEE: Copy

S.A. ROZATI, S.J. MIRNAJAFIZADEH, Y. FATH ELAHI, M. MOHAMMADZADEH, and M.R. PALIZVAN, “EFFECT OF ADENOSINE A1 RECEPTORS ACTIVITY OF NUCLEUS ACCUMBENS ON AMYGDALA KINDLED SEIZURES IN RATS ,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 7, no. 1, pp. 49–59, 2004, [Online]. Available: https://sid.ir/paper/81235/en

Related Journal Papers