APOLIPOPROTEIN E PLOYMORPHISM IN PATIENTS WITH ALZHEIMER DISEASE IN IRANIAN POPULATION

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KEYKHAEI M.R.; NAJMABADI H.; PASALAR P.; SAHEBJAM F.; JAVAN M.KH.; HAJIBEYGI A.; POURFARZAD F.

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Journal: Pathobiology Research Year:2001 | Volume:4 | Issue:1 Page(s): 47-53

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Title

APOLIPOPROTEIN E PLOYMORPHISM IN PATIENTS WITH ALZHEIMER DISEASE IN IRANIAN POPULATION

Author(s)

Keywords

APLOIPOPROTEINQ4

ALZHEIMER DISEASEQ4

IRANIAN POPULATIONQ4

PCRQ3

Abstract

Alzheimer's dementia (AD) is a progressive neurodegenerative disease which in recognized as the most common form of dementia in the age of 65 years old and above. Diagnosis of this disease is based upon evaluation of cognitive skills, elimination of other dementia associated diseases and cranial CT examination. However, the definitive diagnosis is proved only by neurohistological findings. Although the etiology of the disease is unknown and its' effective treatment is not available, research in the path mechanism of the disease shows a connection between increased frequency of apolipoprotein E4 allele and later onset of AD. The objective of this study was to characterize apoipoprotein E polymorphism's in late onset of AD patients. In this regard, 100 AD patients and 100 individuals (as normal controls) were examined using the PCR method. The result showed that the E4 allele was significantly more frequent in both early and late onset groups (42%) compared to the controls (11%). This data indicates that the Apo E4 could be regarded as a risk factor for AD.

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APA: Copy

KEYKHAEI, M.R., NAJMABADI, H., PASALAR, P., SAHEBJAM, F., JAVAN, M.KH., HAJIBEYGI, A., & POURFARZAD, F.. (2001). APOLIPOPROTEIN E PLOYMORPHISM IN PATIENTS WITH ALZHEIMER DISEASE IN IRANIAN POPULATION. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 4(1), 47-53. SID. https://sid.ir/paper/81265/en

Vancouver: Copy

KEYKHAEI M.R., NAJMABADI H., PASALAR P., SAHEBJAM F., JAVAN M.KH., HAJIBEYGI A., POURFARZAD F.. APOLIPOPROTEIN E PLOYMORPHISM IN PATIENTS WITH ALZHEIMER DISEASE IN IRANIAN POPULATION. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2001;4(1):47-53. Available from: https://sid.ir/paper/81265/en

IEEE: Copy

M.R. KEYKHAEI, H. NAJMABADI, P. PASALAR, F. SAHEBJAM, M.KH. JAVAN, A. HAJIBEYGI, and F. POURFARZAD, “APOLIPOPROTEIN E PLOYMORPHISM IN PATIENTS WITH ALZHEIMER DISEASE IN IRANIAN POPULATION,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 4, no. 1, pp. 47–53, 2001, [Online]. Available: https://sid.ir/paper/81265/en

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