STUDY OF THE THERAPEUTIC EFFECT OF MELATONIN AFTER FOOD DEPRIVATION IN APOPTOSIS AND OXIDATIVE STRESS IN RAT TESTIS

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NASIRAEI MOGHADAM SHIVA; PARIVAR KAZEM; AHMADIANI ABOLHASSAN; MOVAHEDIN MANSOUREH; VAEZ MAHDAVI MOHAMMAD REZA; ROGHANI MEHRDAD; KAZEMINEGAD BEHRANG

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Journal: Pathobiology Research Year:2012 | Volume:15 | Issue:3 Page(s): 80-92

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Title

STUDY OF THE THERAPEUTIC EFFECT OF MELATONIN AFTER FOOD DEPRIVATION IN APOPTOSIS AND OXIDATIVE STRESS IN RAT TESTIS

Author(s)

Keywords

APOPTOSISQ2

FOOD DEPRIVATIONQ3

INEQUALITYQ1

MELATONINQ2

TESTISQ3

Abstract

Objective: The goals of the study are evaluation the effect (s) of FOOD DEPRIVATION as a social stress on TESTIS structure. We also investigated the effects of MELATONIN treatment as an antioxidant component and INEQUALITY on the effect (s) of FOOD DEPRIVATION.Methods: We investigated the improving effects of MELATONIN and social stress (food deprivation) on 42 male rats in 7 groups including control, sham, MELATONIN received (M), FOOD DEPRIVATION (1/3 of control daily food) plus observation (FD), FD+melatonin (FDM), isolated FD (FDi), and FDi+melatonin (FDMi) groups. After 14 days, rats’ testes were studied using immuno histochemistry and TUNEL assays to determine the number of apoptotic cells. Biochemical evaluation was taken on malodialdehide (MDA) and glutathione (GSH). ANOVA and Tukey’s tests were done to analyse the data. P<0.05 was considered statistically significant.Results: The results of sham group was declined for similarity to results of control group. In FD group, MDA was increased significantly (P<0.01), GSH was decreased and the number of apoptotic cells was increased, significantly (P<0.01). In FDi group, there was no effect on the ratio of oxidative stress compared to the control group. MELATONIN treatment could decrease apoptotic cells (P<0.05) and MDA concentration (P<0.05) in the FD group.Conclusion: FOOD DEPRIVATION can induce oxidative stress which is associated with increasment of apoptotic cells in TESTIS. Isolation can compensate these effects. These results refer to INEQUALITY. Since MELATONIN is recognized for its anti-oxidative and improving effects, we have shown involvement of oxidative stress mechanisms on the stress of FOOD DEPRIVATION with INEQUALITY.

Cites

EFFECT OF FOOD RESTRICTION, FOOD DEPRIVATION AND FOOD INEQUALITY ON ANXIETY-LIKE BEHAVIOR IN RATS

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APA: Copy

NASIRAEI MOGHADAM, SHIVA, PARIVAR, KAZEM, AHMADIANI, ABOLHASSAN, MOVAHEDIN, MANSOUREH, VAEZ MAHDAVI, MOHAMMAD REZA, ROGHANI, MEHRDAD, & KAZEMINEGAD, BEHRANG. (2012). STUDY OF THE THERAPEUTIC EFFECT OF MELATONIN AFTER FOOD DEPRIVATION IN APOPTOSIS AND OXIDATIVE STRESS IN RAT TESTIS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 15(3), 80-92. SID. https://sid.ir/paper/81321/en

Vancouver: Copy

NASIRAEI MOGHADAM SHIVA, PARIVAR KAZEM, AHMADIANI ABOLHASSAN, MOVAHEDIN MANSOUREH, VAEZ MAHDAVI MOHAMMAD REZA, ROGHANI MEHRDAD, KAZEMINEGAD BEHRANG. STUDY OF THE THERAPEUTIC EFFECT OF MELATONIN AFTER FOOD DEPRIVATION IN APOPTOSIS AND OXIDATIVE STRESS IN RAT TESTIS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2012;15(3):80-92. Available from: https://sid.ir/paper/81321/en

IEEE: Copy

SHIVA NASIRAEI MOGHADAM, KAZEM PARIVAR, ABOLHASSAN AHMADIANI, MANSOUREH MOVAHEDIN, MOHAMMAD REZA VAEZ MAHDAVI, MEHRDAD ROGHANI, and BEHRANG KAZEMINEGAD, “STUDY OF THE THERAPEUTIC EFFECT OF MELATONIN AFTER FOOD DEPRIVATION IN APOPTOSIS AND OXIDATIVE STRESS IN RAT TESTIS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 15, no. 3, pp. 80–92, 2012, [Online]. Available: https://sid.ir/paper/81321/en

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