NON-FUNCTIONING PITUITARY ADENOMA: CLINICOPATHOLOGICAL STUDY OF 85 CASES

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MAHTA A.; HAGHPANAH V.; LASHKARI L.; HESHMAT H.; ARDESHIR LARIJANI MOHAMMAD BAGHER; TAVANGAR M.

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Journal Paper

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Journal: Journal of Sabzevar University of Medical Sciences Year:2006 | Volume:13 | Issue:2 (40) Page(s): 99-104

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Title

NON-FUNCTIONING PITUITARY ADENOMA: CLINICOPATHOLOGICAL STUDY OF 85 CASES

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Keywords

NON-FUNCTIONINGQ3

PITUITARYQ2

ADENOMAQ3

NFPAQ3

IMMUNOHISTOCHEMISTRYQ3

MIB-1Q3

Abstract

Background and Purpose: PITUITARY ADENOMAs without clinically active hypertension are termed as NON-FUNCTIONING ADENOMA (NFPA). These tumors represent about one quarter of all PITUITARY tumors. Immunohistochemical methods are the gold standard methods of identifying them. The Ki-67 is a nuclear antigen detected by the monoclonal antibody MIB-1, whose labeling index (LI) is considered as a marker of normal and abnormal cell proliferation.Methods and Materials: In this clinicopathological study, 85 cases of NFPAs were analyzed immunohistochemically. Results: MIB-1 LI was measured in all surgical specimens, which was higher than 5% only in 5 cases. Also, 18 cases were immunoactive to one or two adenohypophysial hormones.Conclusion: NFPAs comprise several pathologically different types of tumors, some of which are potentially hormone producing tumors. However, probable defects in hormone secretion may be the cause of not increasing the adenohypophysial hormone levels in the serum and consequent syndromes.

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APA: Copy

MAHTA, A., HAGHPANAH, V., LASHKARI, L., HESHMAT, H., ARDESHIR LARIJANI, MOHAMMAD BAGHER, & TAVANGAR, M.. (2006). NON-FUNCTIONING PITUITARY ADENOMA: CLINICOPATHOLOGICAL STUDY OF 85 CASES. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 13(2 (40)), 99-104. SID. https://sid.ir/paper/81841/en

Vancouver: Copy

MAHTA A., HAGHPANAH V., LASHKARI L., HESHMAT H., ARDESHIR LARIJANI MOHAMMAD BAGHER, TAVANGAR M.. NON-FUNCTIONING PITUITARY ADENOMA: CLINICOPATHOLOGICAL STUDY OF 85 CASES. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;13(2 (40)):99-104. Available from: https://sid.ir/paper/81841/en

IEEE: Copy

A. MAHTA, V. HAGHPANAH, L. LASHKARI, H. HESHMAT, MOHAMMAD BAGHER ARDESHIR LARIJANI, and M. TAVANGAR, “NON-FUNCTIONING PITUITARY ADENOMA: CLINICOPATHOLOGICAL STUDY OF 85 CASES,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 2 (40), pp. 99–104, 2006, [Online]. Available: https://sid.ir/paper/81841/en

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