EFFECTS OF NORHARMANE ON MEMORY RETENTION IN PASSIVE AVOIDANCE LEARNING IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ESMAEILI MOHAMMAD HOSSEIN; SOFIABADI MOHAMMAD; HAGHDOST HASHEM; LOTFI AIDA; Najafi Mahshid

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2015 | Volume:22 | Issue:5 Page(s): 862-869

Download Full-Text

Persian Verion

View:

771

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF NORHARMANE ON MEMORY RETENTION IN PASSIVE AVOIDANCE LEARNING IN RATS

Author(s)

Keywords

NORHARMANEQ2

PASSIVE AVOIDANCE LEARNINGQ2

MEMORY RETENTIONQ1

Abstract

Background & Objectives: Although benzodiazepine drugs have notably anxiolytic and amnesic properties, some of b-carbolines, as their inverse agonists, have a stimulating effect on the dopaminergic system and also increase dopamine levels in hippocampus, and could exert anxiogenic and learning-enhancing actions. The goal of present study was to investigate the effects of benzodiazepine receptor inverse agonist NORHARMANE on MEMORY RETENTION of PASSIVE AVOIDANCE LEARNING in rats.Materials & Methods: 40 male wistar rats were divided into control, alcohol and NORHARMANE groups. All rates were trained in a passive avoidance task (50Hz, 1mA, for 3sec). Alcohol (0.2ml) or NORHARMANE (0.5, 1, 2 mg/kg, i.p.) were injected immediately after training. Retention test was done 48h later. MEMORY RETENTION of each animal was measured as latency takes to enter the dark chamber of the task.results: After-training injection of NORHARMANE improves MEMORY RETENTION in a dose-dependent manner, So that the time spent in the light chamber area before entering to the dark area and Total time spent in the light chamber in the NORHARMANE groups were more than control group. These times in the NORHARMANE (2 mg/kg) group was significantly higher than control group (p<0.001).Conclusion: According to the findings, NORHARMANE, as inverse agonists of benzodiazepine receptors in the low doses, through GABA receptors stimulation, improves MEMORY RETENTION and so may be useful for memory improvement.

Cites

No record.

References

No record.

Cite

APA: Copy

ESMAEILI, MOHAMMAD HOSSEIN, SOFIABADI, MOHAMMAD, HAGHDOST, HASHEM, LOTFI, AIDA, & Najafi, Mahshid. (2015). EFFECTS OF NORHARMANE ON MEMORY RETENTION IN PASSIVE AVOIDANCE LEARNING IN RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 22(5), 862-869. SID. https://sid.ir/paper/81855/en

Vancouver: Copy

ESMAEILI MOHAMMAD HOSSEIN, SOFIABADI MOHAMMAD, HAGHDOST HASHEM, LOTFI AIDA, Najafi Mahshid. EFFECTS OF NORHARMANE ON MEMORY RETENTION IN PASSIVE AVOIDANCE LEARNING IN RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;22(5):862-869. Available from: https://sid.ir/paper/81855/en

IEEE: Copy

MOHAMMAD HOSSEIN ESMAEILI, MOHAMMAD SOFIABADI, HASHEM HAGHDOST, AIDA LOTFI, and Mahshid Najafi, “EFFECTS OF NORHARMANE ON MEMORY RETENTION IN PASSIVE AVOIDANCE LEARNING IN RATS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 5, pp. 862–869, 2015, [Online]. Available: https://sid.ir/paper/81855/en

Related Journal Papers