INCREASED SOLUBLE FAS SERUM LEVELS AND ITS RELATIONSHIP WITH THYROID AUTOANTIBODY POSITIVITY IN UNTREATED GRAVES HYPERTHYROIDISM IN TEHRAN, IRAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHOUSHTARIZADEH P.; HAGHPANAH V.; RAJABI POUR B.; HESHMAT RAMIN; SHARGHI S.; LASHKARI A.; SEDDIGHI N.; ARDESHIR LARIJANI MOHAMMAD BAGHER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2006 | Volume:13 | Issue:3 (41) Page(s): 116-121

Download Full-Text

Persian Verion

View:

704

Download:

Cites:

Information Journal Paper

Title

INCREASED SOLUBLE FAS SERUM LEVELS AND ITS RELATIONSHIP WITH THYROID AUTOANTIBODY POSITIVITY IN UNTREATED GRAVES HYPERTHYROIDISM IN TEHRAN, IRAN

Author(s)

Keywords

ANTIGENQ3

CD 65Q3

GRAVES’ DISEASEQ4

SOLUBLE FASQ3

Abstract

Background and Purpose: Serum SOLUBLE FAS (sFas) is found in low concentrations in the sera of healthy subjects and it elevated in patients with autoimmune diseases, malignancy and inflammatory diseases. The Fas molecules play some role in the pathogenesis of GRAVES’ DISEASE through interfering with the Fas-FasL interaction. Therefore, this study was conducted to evaluate the relationship between SOLUBLE FAS serum level and thyroid autoantibodies. Methods and Materials: In order to determine the association of serum sFas level with thyroid autoantibodies, we evaluated the serum levels of sFas and thyroid antibodies in 31 untreated GD patients and 37 respective healthy controls.Results: sFas serum level was reported to be higher in patients than in healthy subjects (P<0.005). Odds ratio of thyroid autoantibodies serum positivity for serum sFas quartiles were 1.99 (95% CI: 1.2 - 3.3) for TSH receptor antibodies (TRAb), 1.68 (95% CI: 1.04-2.71) for thyroid peroxidase antibodies (TPOAb), 1.13 (95% CI: 0.7-1.83) for antithyroid microsomal antibodies and 1.17 (95% CI: 0.73-1.88) for antithyroglobulin antibodies. However, Odds ratio of quartiles of serum titer of thyroid autoantibodies for serum sFas were not significant. There was a moderate but significant direct correlation between serum levels of sFas and free T4 (r=0.392) and free T3 (r=0.360) in GD patients (p<0.05).Conclusion: In this study, a significant relationship was observed to exist between thyroid autoantibodies (TRAb and TPOAb) serum positivity and sFas levels, which may suggest the role of sFas in the Graves' Disease.

Cites

No record.

References

No record.

Cite

APA: Copy

SHOUSHTARIZADEH, P., HAGHPANAH, V., RAJABI POUR, B., HESHMAT, RAMIN, SHARGHI, S., LASHKARI, A., SEDDIGHI, N., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2006). INCREASED SOLUBLE FAS SERUM LEVELS AND ITS RELATIONSHIP WITH THYROID AUTOANTIBODY POSITIVITY IN UNTREATED GRAVES HYPERTHYROIDISM IN TEHRAN, IRAN. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 13(3 (41)), 116-121. SID. https://sid.ir/paper/81933/en

Vancouver: Copy

SHOUSHTARIZADEH P., HAGHPANAH V., RAJABI POUR B., HESHMAT RAMIN, SHARGHI S., LASHKARI A., SEDDIGHI N., ARDESHIR LARIJANI MOHAMMAD BAGHER. INCREASED SOLUBLE FAS SERUM LEVELS AND ITS RELATIONSHIP WITH THYROID AUTOANTIBODY POSITIVITY IN UNTREATED GRAVES HYPERTHYROIDISM IN TEHRAN, IRAN. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;13(3 (41)):116-121. Available from: https://sid.ir/paper/81933/en

IEEE: Copy

P. SHOUSHTARIZADEH, V. HAGHPANAH, B. RAJABI POUR, RAMIN HESHMAT, S. SHARGHI, A. LASHKARI, N. SEDDIGHI, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “INCREASED SOLUBLE FAS SERUM LEVELS AND ITS RELATIONSHIP WITH THYROID AUTOANTIBODY POSITIVITY IN UNTREATED GRAVES HYPERTHYROIDISM IN TEHRAN, IRAN,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 3 (41), pp. 116–121, 2006, [Online]. Available: https://sid.ir/paper/81933/en

Related Journal Papers