INVESTIGATING THE EFFECTS OF ORAL MAGNESIUM SULFATE ON SKIN MICROVASCULAR BLOOD FLOW IN DIABETIC RATS

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HEYDARIANPOUR A.; AZADI MOGHTADER M.; SADEGHIAN E.

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Journal: Journal of Sabzevar University of Medical Sciences Year:2009 | Volume:15 | Issue:4 (50) Page(s): 200-206

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Title

INVESTIGATING THE EFFECTS OF ORAL MAGNESIUM SULFATE ON SKIN MICROVASCULAR BLOOD FLOW IN DIABETIC RATS

Author(s)

HEYDARIANPOUR A. | AZADI MOGHTADER M. | SADEGHIAN E. | Issue Writer Certificate

Keywords

MAGNESIUM SULFATEQ2

DIABETESQ2

SKIN MICROVASCULAR BLOOD FLOWQ3

Abstract

Background and Purpose: Magnesium deficiency has recently been proposed as a novel factor implicated in the pathogenesis of DIABETES complications such as vascular disorders but the mechanism has not been completely clarified. The present study was designed to determine the effect of oral MAGNESIUM SULFATE administration on SKIN MICROVASCULAR BLOOD FLOW in diabetic rats.Methods and Materials: In this experimental study, 50 male Wister rats (200–250 g) were divided into two diabetic and one control groups. One diabetic group received MAGNESIUM SULFATE (10 g/L) in drinking water for a 10-week period. The other two groups received only tap water. After 10 weeks, animals were deeply anaesthetized and placed on a heating pad to maintain their body temperature at 37±0.5°C. Laser Doppler flow meter was used to measure the relative changes in skin blood flow. After stabilization, we used ACh, SNP, L-NNA+ MAGNESIUM SULFATE (0.1M) in control and experimental animal by microsyringe pump microinjection. In order to analyze the obtained data, Student t-test and One-way ANOVA were used in SPSS with p<0.05.Results: Sodium nitroprusside and acetyl choline-induced cutaneous perfusion were increased significantly in the Mgtreated diabetic group compared to control diabetic group (p< 0.01) , non-diabetic group (p< 0.05) and diabetic group(p< 0.05) respectively. Also, local microinjection of MAGNESIUM SULFATE (0.1M) increased cutaneous blood flow in all groups (p< 0.01).However, the administration of Nw-Nitro-L-Arginine (LNNA; NO synthase inhibitor) prior to MAGNESIUM SULFATE attenuated (p < 0.05) but did not abolish the increase in cutaneous blood flow in trained diabetic and normal rats. Conclusion: From the results of this study, it may be concluded that the chronic use of MAGNESIUM SULFATE with the potentiation of nitric oxide pathway can improve SKIN MICROVASCULAR BLOOD FLOW of diabetic rats.

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APA: Copy

HEYDARIANPOUR, A., AZADI MOGHTADER, M., & SADEGHIAN, E.. (2009). INVESTIGATING THE EFFECTS OF ORAL MAGNESIUM SULFATE ON SKIN MICROVASCULAR BLOOD FLOW IN DIABETIC RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 15(4 (50)), 200-206. SID. https://sid.ir/paper/82545/en

Vancouver: Copy

HEYDARIANPOUR A., AZADI MOGHTADER M., SADEGHIAN E.. INVESTIGATING THE EFFECTS OF ORAL MAGNESIUM SULFATE ON SKIN MICROVASCULAR BLOOD FLOW IN DIABETIC RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;15(4 (50)):200-206. Available from: https://sid.ir/paper/82545/en

IEEE: Copy

A. HEYDARIANPOUR, M. AZADI MOGHTADER, and E. SADEGHIAN, “INVESTIGATING THE EFFECTS OF ORAL MAGNESIUM SULFATE ON SKIN MICROVASCULAR BLOOD FLOW IN DIABETIC RATS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 4 (50), pp. 200–206, 2009, [Online]. Available: https://sid.ir/paper/82545/en

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