ANTI-LEISHMANIAL EFFECT OF NANOSILVER SOLUTIONS ON LEISHMANIA TROPICA PROMASTIGOTES BY IN-VITRO ASSAY

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KHOSRAVI AHMAD; SHARIFI IRAJ; BARATI MOHAMMAD; ZAREAN MAHDI; HAKIMI PARIZI MARAYAM

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Journal: Zahedan Journal of Research in Medical Sciences Year:2011 | Volume:13 | Issue:7 Page(s): 8-11

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Title

ANTI-LEISHMANIAL EFFECT OF NANOSILVER SOLUTIONS ON LEISHMANIA TROPICA PROMASTIGOTES BY IN-VITRO ASSAY

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Keywords

LEISHMANIA TROPICAQ2

NANOSILVER PARTICLESQ2

COLORIMETRIC ASSAYQ3

Abstract

Background: At present, NANOSILVER PARTICLES are used against a broad spectrum of microbial agents. The objective of this study was to evaluate the anti-leishmanial effect of nanosilver solutions on L. tropica promastigotes as compared with the trivalent antimony compound by COLORIMETRIC ASSAY.Materials and Method: Promastigots of L. tropica were cultured in RPMI-1640 consisting of 10% fetal calf serum (FCS) and antibiotics at 24±10oC. The effect of various concentrations of nanosilver solutions was evaluated in comparison with tartar emetic. Optical density as the result of tetrazolium salts (MTT) reduction by the promastigotes into a formozan product and it was calculated by Elisa reader and IC50 (50% inhibitory concentration), subsequently.Results: Both, NANOSILVER PARTICLES and tartar emetic inhibited the growth of L. tropica promastigotes. The IC50 for nanosilver solutions was significantly higher (14.9 mg/mL) than the corresponding value (5.3 mg/mL) for the control drug (p<0.001).Conclusion: Since NANOSILVER PARTICLES showed an effective anti-leishmanial activity, further works are required to evaluate the effect in animal model or human volunteers.

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APA: Copy

KHOSRAVI, AHMAD, SHARIFI, IRAJ, BARATI, MOHAMMAD, ZAREAN, MAHDI, & HAKIMI PARIZI, MARAYAM. (2011). ANTI-LEISHMANIAL EFFECT OF NANOSILVER SOLUTIONS ON LEISHMANIA TROPICA PROMASTIGOTES BY IN-VITRO ASSAY. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 13(7), 8-11. SID. https://sid.ir/paper/84363/en

Vancouver: Copy

KHOSRAVI AHMAD, SHARIFI IRAJ, BARATI MOHAMMAD, ZAREAN MAHDI, HAKIMI PARIZI MARAYAM. ANTI-LEISHMANIAL EFFECT OF NANOSILVER SOLUTIONS ON LEISHMANIA TROPICA PROMASTIGOTES BY IN-VITRO ASSAY. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2011;13(7):8-11. Available from: https://sid.ir/paper/84363/en

IEEE: Copy

AHMAD KHOSRAVI, IRAJ SHARIFI, MOHAMMAD BARATI, MAHDI ZAREAN, and MARAYAM HAKIMI PARIZI, “ANTI-LEISHMANIAL EFFECT OF NANOSILVER SOLUTIONS ON LEISHMANIA TROPICA PROMASTIGOTES BY IN-VITRO ASSAY,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 13, no. 7, pp. 8–11, 2011, [Online]. Available: https://sid.ir/paper/84363/en

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