SERUM COPPER IN THALASSEMIC ADOLESCENTS: RELATIONS TO BONE MASS ABNORMALITIES

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BEKHEIRNIA M.R.; SHAMSHIRSAZ A.A.; KAMGAR M.; ERFANZADEH G.; BOUZARI N.; TABATABAEI S.M.; ARDESHIR LARIJANI MOHAMMAD BAGHER

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Journal: Zahedan Journal of Research in Medical Sciences Year:2003 | Volume:5 | Issue:2 Page(s): 79-86

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Title

SERUM COPPER IN THALASSEMIC ADOLESCENTS: RELATIONS TO BONE MASS ABNORMALITIES

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Keywords

SERUM COPPERQ3

THALASSEMIAQ3

BONE MINERAL DENSITYQ3

COPPER INTAKEQ4

Abstract

This study aims at determining SERUM COPPER profile in β-thalassemic patients and the possible association with BONE MINERAL DENSITY (BMD) abnormalities. In one hundred thirty one transfusion-dependent β-thalassemic adolescents, serum levels of copper were measured by Flame-Atomic Absorption Spectrophotometry. BMD values at lumbar (L1-L4) and femoral neck were determined by dual x-ray absorptiometry (DXA). Food frequency questionnaire was used to determine patients' dietary copper and calcium intake. Patients’ history of treatment and demographic data were obtained. Low SERUM COPPER was seen in 67.7% of female and 75.7% of male patients. Female patients with low therapeutic index (p<0.025) had higher SERUM COPPER level (p<0.05). Mean of COPPER INTAKEs were 0.41±1.08 mg/day in the evaluated patients. SERUM COPPER showed no association with BMD abnormalities neither in lumbar nor in femoral areas. We need more studies to explore different causes of low SERUM COPPER levels in our patients; however dietary modification and oral supplementation (under close observation) in these patients are recommended.

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APA: Copy

BEKHEIRNIA, M.R., SHAMSHIRSAZ, A.A., KAMGAR, M., ERFANZADEH, G., BOUZARI, N., TABATABAEI, S.M., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2003). SERUM COPPER IN THALASSEMIC ADOLESCENTS: RELATIONS TO BONE MASS ABNORMALITIES. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 5(2), 79-86. SID. https://sid.ir/paper/84391/en

Vancouver: Copy

BEKHEIRNIA M.R., SHAMSHIRSAZ A.A., KAMGAR M., ERFANZADEH G., BOUZARI N., TABATABAEI S.M., ARDESHIR LARIJANI MOHAMMAD BAGHER. SERUM COPPER IN THALASSEMIC ADOLESCENTS: RELATIONS TO BONE MASS ABNORMALITIES. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2003;5(2):79-86. Available from: https://sid.ir/paper/84391/en

IEEE: Copy

M.R. BEKHEIRNIA, A.A. SHAMSHIRSAZ, M. KAMGAR, G. ERFANZADEH, N. BOUZARI, S.M. TABATABAEI, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “SERUM COPPER IN THALASSEMIC ADOLESCENTS: RELATIONS TO BONE MASS ABNORMALITIES,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 5, no. 2, pp. 79–86, 2003, [Online]. Available: https://sid.ir/paper/84391/en

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